|
Symbol Name ID |
Braf
Braf transforming gene MGI:88190 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Anorexia |
Dysphagia |
Impaired oropharyngeal swallow response |
Oculomotor apraxia |
Peripheral axonal neuropathy |
Hydrocephalus |
Cerebral cortical atrophy |
Hypoplasia of the frontal lobes |
Aplasia/Hypoplasia of the corpus callosum |
EEG abnormality |
Abnormality of speech or vocalization |
Dysarthria |
Tongue thrusting |
Cognitive impairment |
Intellectual disability |
Global developmental delay |
Seizure |
| Disease(s) Associated with BRAF | |||||||||||||||||
| cardiofaciocutaneous syndrome | |||||||||||||||||
| cardiofaciocutaneous syndrome 1 | |||||||||||||||||
| Noonan syndrome 7 | |||||||||||||||||
| Noonan syndrome with multiple lentigines 3 | |||||||||||||||||
| pancreatic cancer |
| Mouse Phenotypes | nervous system phenotype |
convulsive seizures |
intraventricular hemorrhage |
increased neuron apoptosis |
impaired neuron differentiation |
abnormal neuronal precursor proliferation |
increased neuronal precursor proliferation |
abnormal adenohypophysis morphology |
small adenohypophysis |
increased susceptibility to ischemic brain injury |
abnormal telencephalon development |
decreased brain weight |
abnormal hippocampus granule cell layer |
abnormal cerebral cortex pyramidal cell morphology |
abnormal somatosensory cortex morphology |
abnormal stratification in cerebral cortex |
abnormal visual cortex morphology |
thin cerebral cortex |
abnormal cerebellum morphology |
abnormal Purkinje cell morphology |
abnormal Purkinje cell dendrite morphology |
decreased Purkinje cell number |
abnormal cerebellar molecular layer |
abnormal cerebellum vermis lobule I morphology |
abnormal cerebellum vermis lobule II morphology |
abnormal cerebellum vermis lobule III morphology |
abnormal cerebellum vermis lobule V morphology |
abnormal cerebellum vermis lobule morphology |
abnormal cerebellum vermis lobule VII morphology |
abnormal cerebellum vermis lobule X morphology |
cerebellum hypoplasia |
abnormal astrocyte morphology |
abnormal innervation |
abnormal neuron morphology |
abnormal dorsal root ganglion morphology |
abnormal nervous system electrophysiology |
abnormal neuron physiology |
reduced long-term potentiation |
|
| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||||||
| Braftm1(ARAF)Urr/Braftm1(ARAF)Urr | |||||||||||||||||||||||||||||||||||||||
| Braftm1.1Sva/Braftm1.1Sva | |||||||||||||||||||||||||||||||||||||||
| Braftm1.1Wds/Braftm1.1Wds | |||||||||||||||||||||||||||||||||||||||
| Braftm1Zim/Braftm1Zim | |||||||||||||||||||||||||||||||||||||||
| Braftm1Bbd/Braf+ | |||||||||||||||||||||||||||||||||||||||
| Braftm1Sva/Braftm1Sva Tg(Camk2a-cre)1557Sva/0 (conditional) |
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| Braftm2.1Urr/Braftm2.1Urr Tg(Nes-cre)1Kln/0 (conditional) |
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| Braftm2Urr/Braftm2Urr Tg(Nes-cre)1Kln/0 (conditional) |
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| Braftm1Cpri/Braf+ Scn10atm2(cre)Jwo/Scn10a+ (conditional) |
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| Braftm1Sva/Braftm1.1Sva Tg(Nes-cre)1Kln/0 (conditional) |
* | ||||||||||||||||||||||||||||||||||||||
| Braftm1Wds/Braftm1.1Wds Tg(Nes-cre)1Kln/0 (conditional) |
* | ||||||||||||||||||||||||||||||||||||||
| Braftm2Cpri/Braf+ Tg(CMV-cre)1Cgn/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/21/2024 MGI 6.23 |
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