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Symbol
Name
ID 		Bmp4
bone morphogenetic protein 4
MGI:88180
Phenotype annotations related to nervous system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Microcephaly
Stroke
Anterior hypopituitarism
Photophobia
Delayed CNS myelination
Morphological central nervous system abnormality
Ventriculomegaly
Cerebral cortical atrophy
Aplasia/Hypoplasia of the corpus callosum
Agenesis of corpus callosum
Inferior cerebellar vermis hypoplasia
Cerebellar hypoplasia
Myelopathy
Spinal cord compression
Aplasia of the optic tract
Absent speech
Hyperreflexia
Global developmental delay
Seizure
Disease(s) Associated with BMP4
atrial heart septal defect
ossification of the posterior longitudinal ligament of spine
syndromic microphthalmia 6
tooth agenesis

Mouse Phenotypes
nervous system phenotype
abnormal radial glial cell morphology
abnormal neural tube closure
absent Rathke's pouch
decreased vestibular hair cell stereocilia number
abnormal forebrain development
abnormal hindbrain development
abnormal midbrain development
increased astrocyte number
decreased oligodendrocyte number
abnormal sensory neuron innervation pattern
abnormal optic nerve morphology
abnormal optic disk morphology
absent optic nerve
Availability Mouse Genotype
Bmp4tm1b(EUCOMM)Hmgu/Bmp4tm1b(EUCOMM)Hmgu
Bmp4tm1Blh/Bmp4tm1Blh
Bmp4tm1b(EUCOMM)Hmgu/Bmp4+
Bmp4tm1Blh/Bmp4+
Tg(Eno2-Bmp4)3Jake/0
Bmp4tm3Blh/Bmp4tm3Blh
Foxg1tm1(cre)Skm/Foxg1+  (conditional)		 *
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory