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Symbol
Name
ID

Gars1
glycyl-tRNA synthetase 1
MGI:2449057

Phenotype annotations related to nervous system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Abnormal motor nerve conduction velocity	Hyperreflexia	Hyporeflexia	Unsteady gait	Postural instability	Peripheral neuropathy	Motor polyneuropathy	Distal sensory impairment	Impaired vibratory sensation
Disease(s) Associated with GARS1	Abnormal motor nerve conduction velocity	Hyperreflexia	Hyporeflexia	Unsteady gait	Postural instability	Peripheral neuropathy	Motor polyneuropathy	Distal sensory impairment	Impaired vibratory sensation
autosomal dominant distal hereditary motor neuronopathy 5
Charcot-Marie-Tooth disease type 2D

Mouse Phenotypes

nervous system phenotype

abnormal nervous system morphology

abnormal innervation pattern to muscle

abnormal axon morphology

abnormal sensory neuron morphology

abnormal neuromuscular synapse morphology

abnormal sciatic nerve morphology

axon degeneration

demyelination

abnormal nerve conduction

decreased nerve conduction velocity

abnormal synaptic transmission

abnormal PNS synaptic transmission

abnormal endplate potential

Availability

Mouse Genotype

Gars1^C201R/Gars1⁺

*

Gars1^C201R/Gars1⁺
Tg(Thy1-YFP)16Jrs/?

Gars1^C201R/Gars1^Nmf249

Gars1^em1Rwb/Gars1^em2Rwb

Gars1^Nmf249/Gars1⁺

*

Gars1^Nmf249/Gars1⁺
Tg(Thy1-YFP)16Jrs/?

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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