About Help FAQ

Symbol
Name
ID

Setx
senataxin
MGI:2443480

Phenotype annotations related to nervous system

Darker colors indicate more annotations

Human Phenotypes

Dysphagia

Oculomotor apraxia

Spastic paraplegia

Difficulty walking

Degeneration of anterior horn cells

Abnormal lower motor neuron morphology

Amyotrophic lateral sclerosis

Diffuse axonal swelling

Peripheral axonal degeneration

Axonal degeneration

Peripheral axonal neuropathy

Chronic axonal neuropathy

Pontocerebellar atrophy

Cerebellar vermis atrophy

Cerebellar atrophy

Pallor of dorsal columns of the spinal cord

Atrophy of the spinal cord

Ataxia

Gait ataxia

Progressive gait ataxia

Limb ataxia

Choreoathetosis

Chorea

Clonus

Tremor

Postural tremor

Head tremor

Abnormal pyramidal sign

Babinski sign

Decreased motor nerve conduction velocity

Decreased compound muscle action potential amplitude

Dysarthria

Hyperreflexia

Reduced tendon reflexes

Areflexia

Hyporeflexia

Dystonia

Gait disturbance

Gait imbalance

Muscle fibrillation

Polyneuropathy

Sensorimotor neuropathy

Somatic sensory dysfunction

Impaired distal tactile sensation

Impaired proprioception

Impaired distal vibration sensation

Disease(s) Associated with SETX

amyotrophic lateral sclerosis type 4

spinocerebellar ataxia with axonal neuropathy 2

Mouse Phenotypes		increased susceptibility to neuronal excitotoxicity	abnormal motor neuron morphology	motor neuron degeneration	abnormal neuromuscular synapse morphology	abnormal neuron physiology
Availability	Mouse Genotype
	Setx^tm1.1Als/Setx⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/21/2024 MGI 6.23