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Symbol
Name
ID
Nlgn1
neuroligin 1
MGI:2179435
Phenotype annotations related to nervous system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
EEG abnormality
Abnormal nonverbal communicative behavior
Delayed speech and language development
Lack of spontaneous play
Impaired ability to form peer relationships
Autism
Inflexible adherence to routines
Motor stereotypy
Restrictive behavior
Intellectual disability
Seizure
Disease(s) Associated with NLGN1
autistic disorder

Mouse Phenotypes
nervous system phenotype
abnormal CNS synaptic transmission
decreased excitatory postsynaptic current amplitude
Availability Mouse Genotype
Nlgn1em1Taku/Nlgn1em1Taku *
Nlgn1tm1Bros/Nlgn1tm1Bros
Nlgn1em1Taku/Nlgn1+ *
Tg(Thy1-Nlgn1)6Hnes/0 *
Nlgn1tm1.1Sud/Nlgn1tm1.1Sud
Tg(Pcp2-cre)2Mpin/?  (conditional)
*

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/21/2024
MGI 6.23
The Jackson Laboratory