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Symbol
Name
ID

Foxp2
forkhead box P2
MGI:2148705

Phenotype annotations related to nervous system

Darker colors indicate more annotations

Human Phenotypes

Drooling

Abnormal basal ganglia morphology

Abnormal caudate nucleus morphology

Caudate atrophy

Poor fine motor coordination

Poor gross motor coordination

Oromotor apraxia

Speech apraxia

EEG abnormality

Abnormal nonverbal communicative behavior

Abnormality of speech or vocalization

Abnormal prosody

Delayed speech and language development

Expressive language delay

Receptive language delay

Dysarthria

Incomprehensible speech

Poor speech

Deficit in grammar

Delusion

Schizophrenia

Hallucinations

Negativism

Lack of spontaneous play

Delayed early-childhood social milestone development

Impaired ability to form peer relationships

Autistic behavior

Autism

Hyperactivity

Attention deficit hyperactivity disorder

Inflexible adherence to routines

Motor stereotypy

Restrictive behavior

Social and occupational deterioration

Intellectual disability

Specific learning disability

Dyslexia

Seizure

Disease(s) Associated with FOXP2

attention deficit hyperactivity disorder

autistic disorder

dyslexia

schizophrenia

speech-language disorder-1

Mouse Phenotypes

abnormal radial glial cell morphology

abnormal cerebellar foliation

reduced cerebellar foliation

abnormal cerebellum external granule cell layer morphology

decreased brain size

abnormal cerebellum morphology

abnormal cerebellar Purkinje cell layer

abnormal Purkinje cell dendrite morphology

thin cerebellar molecular layer

small cerebellum

abnormal neurite morphology

abnormal dendrite morphology

abnormal synaptic plasticity

abnormal long-term depression

reduced long-term depression

enhanced paired-pulse facilitation

Availability

Mouse Genotype

Foxp2^N549K/Foxp2^N549K

Foxp2^R552H/Foxp2^R552H

Foxp2^S321X/Foxp2^S321X

Foxp2^tm1Bux/Foxp2^tm1Bux

Foxp2^tm1Momo/Foxp2^tm1Momo

Foxp2^tm2.1Woen/Foxp2^tm2.1Woen

Foxp2^R552H/Foxp2⁺

Foxp2^tm1Bux/Foxp2⁺

Foxp2^tm1Sfis/Foxp2^tm1.2Sfis
Edil3^{Tg(Sox2-cre)1Amc}/? (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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