Symbol
Name
ID

Clp1
CLP1, cleavage and polyadenylation factor I subunit
MGI:2138968

Phenotype annotations related to nervous system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Microcephaly

Progressive microcephaly

Spasticity

Delayed myelination

Abnormal brainstem morphology

Ventriculomegaly

Abnormal cerebral cortex morphology

Simplified gyral pattern

Cerebral cortical atrophy

Hypoplasia of the corpus callosum

Reduced cerebral white matter volume

Syringomyelia

Reduced eye contact

Absent speech

Delayed speech and language development

Irritability

Intellectual disability

Hyperreflexia

Encephalopathy

Global developmental delay

Delayed fine motor development

Delayed gross motor development

Sensorimotor neuropathy

Seizure

Disease(s) Associated with CLP1

pontocerebellar hypoplasia type 10

Mouse Phenotypes

nervous system phenotype

increased neuron apoptosis

defasiculated phrenic nerve

abnormal microglial cell morphology

decreased brain weight

decreased brain size

thin cerebral cortex

abnormal olfactory bulb morphology

abnormal cerebellar hemisphere morphology

abnormal cerebellum vermis morphology

abnormal cerebellum dentate nucleus morphology

cerebellum atrophy

abnormal phrenic nerve innervation pattern to diaphragm

decreased motor neuron number

motor neuron degeneration

abnormal axon morphology

decreased neuron number

abnormal neuromuscular synapse morphology

abnormal sciatic nerve morphology

decreased spinal cord size

axon degeneration

Availability

Mouse Genotype

Clp1^em1Slac/Clp1^em1Slac

Clp1^tm1.1Pngr/Clp1^tm1.1Pngr
Tg(Mnx1-Clp1,-EGFP)#Pngr/0

Clp1^tm1.1Pngr/Clp1^tm1.1Pngr

Clp1^tm1.1Pngr/Clp1^tm1.1Pngr
Tg(Hlxb9-GFP)1Tmj/0

Clp1^em1Slac/Clp1^em2Slac

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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