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Symbol
Name
ID

Wdr62
WD repeat domain 62
MGI:1923696

Phenotype annotations related to nervous system

Darker colors indicate more annotations

Human Phenotypes

Microcephaly

Spastic tetraparesis

Ventriculomegaly

Lissencephaly

Pachygyria

Polymicrogyria

Simplified gyral pattern

Hypoplasia of the frontal lobes

Agenesis of corpus callosum

Hypoplasia of the corpus callosum

Schizencephaly

Abnormality of neuronal migration

Gray matter heterotopia

Hemiparesis

EEG abnormality

Delayed speech and language development

Dysarthria

Aggressive behavior

Hyperactivity

Impulsivity

Self-mutilation

Intellectual disability

Intellectual disability, moderate

Intellectual disability, severe

Hyperreflexia

Brisk reflexes

Global developmental delay

Severe global developmental delay

Motor delay

Seizure

Bilateral tonic-clonic seizure

Generalized-onset seizure

Disease(s) Associated with WDR62

primary autosomal recessive microcephaly

primary autosomal recessive microcephaly 2 with or without cortical malformations

Mouse Phenotypes

increased forebrain apoptosis

premature neuronal precursor differentiation

abnormal cortical ventricular zone morphology

decreased brain weight

decreased brain size

abnormal neocortex morphology

abnormal neocortex size

loss of cortex neurons

thin cerebral cortex

decreased neuronal precursor cell number

abnormal nervous system physiology

decreased prepulse inhibition

Availability

Mouse Genotype

Wdr62^em1(IMPC)Tcp/Wdr62^em1(IMPC)Tcp

Wdr62^{Gt(AF0003)Wtsi}/Wdr62^{Gt(AF0003)Wtsi}

Wdr62^tm1.1Jfch/Wdr62^tm1.1Jfch

Wdr62^{tm3a(EUCOMM)Hmgu}/Wdr62^{tm3a(EUCOMM)Hmgu}

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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