|
Symbol Name ID |
Optn
optineurin MGI:1918898 |
| Darker colors indicate more annotations |
| Human Phenotypes | Tongue fasciculations |
Dysphagia |
Spasticity |
Fatigable weakness of bulbar muscles |
Fatigable weakness of swallowing muscles |
Fatigable weakness of respiratory muscles |
Motor neuron atrophy |
Amyotrophic lateral sclerosis |
Neurodegeneration |
Fasciculations |
Paralysis |
Babinski sign |
Dysarthria |
Language impairment |
Depression |
Emotional lability |
Anxiety |
Atypical behavior |
Agitation |
Cognitive impairment |
Frontotemporal dementia |
Sleep abnormality |
Hyperreflexia |
Jaw hyperreflexia |
Loss of ambulation |
| Disease(s) Associated with OPTN | |||||||||||||||||||||||||
| amyotrophic lateral sclerosis | |||||||||||||||||||||||||
| amyotrophic lateral sclerosis type 12 |
| Mouse Phenotypes | retina ganglion cell degeneration |
axon degeneration |
abnormal axonal transport |
|
| Availability | Mouse Genotype | |||
| Optnem1Hyua/Optnem1Hyua | ||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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