Symbol Name ID |
Lrrk2
leucine-rich repeat kinase 2 MGI:1913975 |
* | Aspects of the system are reported to show a normal phenotype. |
Darker colors indicate more annotations |
Human Phenotypes | Hyposmia |
Substantia nigra gliosis |
Lewy bodies |
Bradykinesia |
Parkinsonism |
Parkinsonism with favorable response to dopaminergic medication |
Resting tremor |
Dementia |
Postural instability |
Disease(s) Associated with LRRK2 | |||||||||
Parkinson's disease 8 |
Mouse Phenotypes | nervous system phenotype |
abnormal axon extension |
microgliosis |
abnormal brain interneuron morphology |
abnormal dorsal striatum morphology |
abnormal hippocampal mossy fiber morphology |
tau protein deposits |
abnormal neurite morphology |
abnormal axon morphology |
abnormal dendrite morphology |
abnormal dendritic spine morphology |
increased neuronal precursor cell number |
abnormal action potential |
abnormal excitatory postsynaptic currents |
abnormal excitatory postsynaptic current amplitude |
increased excitatory postsynaptic current frequency |
abnormal synaptic dopamine release |
decreased neurotransmitter release |
increased neurotransmitter release |
abnormal neurotransmitter uptake |
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Availability | Mouse Genotype | ||||||||||||||||||||
Lrrk2tm1.1Cai/Lrrk2tm1.1Cai | * | ||||||||||||||||||||
Lrrk2tm1.1Dlbe/Lrrk2tm1.1Dlbe | |||||||||||||||||||||
Lrrk2tm1.1Hlme/Lrrk2tm1.1Hlme | |||||||||||||||||||||
Lrrk2tm1.1Npa/Lrrk2tm1.1Npa | * | ||||||||||||||||||||
Lrrk2tm1.1Shn/Lrrk2tm1.1Shn | * | ||||||||||||||||||||
Lrrk2tm1.2Npa/Lrrk2tm1.2Npa | * | ||||||||||||||||||||
Lrrk2tm1Arte/Lrrk2tm1Arte | |||||||||||||||||||||
Lrrk2tm1Mjfa/Lrrk2tm1Mjfa | |||||||||||||||||||||
Lrrk2tm2.1Dlbe/Lrrk2tm2.1Dlbe | * | ||||||||||||||||||||
Lrrk2tm2.1Shn/Lrrk2tm2.1Shn | * | ||||||||||||||||||||
Lrrk2tm2Mjfa/Lrrk2tm2Mjfa | * | ||||||||||||||||||||
Lrrk2tm3.1Shn/Lrrk2tm3.1Shn | * | ||||||||||||||||||||
Lrrk2tm1.1Dlbe/Lrrk2+ | |||||||||||||||||||||
Lrrk2tm1.1Hlme/Lrrk2+ | |||||||||||||||||||||
Lrrk2tm4.1Arte/Lrrk2+ | |||||||||||||||||||||
Tg(Lrrk2)6Yue/0 | * | ||||||||||||||||||||
Tg(Lrrk2*G2019S)2Yue/0 | * |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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