Symbol
Name
ID

Gabbr1
gamma-aminobutyric acid type B receptor subunit 1
MGI:1860139

Phenotype annotations related to nervous system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Addictive alcohol use
Disease(s) Associated with GABBR1	Addictive alcohol use
alcohol dependence

Mouse Phenotypes

nervous system phenotype

seizures

audiogenic seizures

clonic seizures

tonic-clonic seizures

absence seizures

sporadic seizures

abnormal axon morphology

abnormal myelin sheath morphology

abnormal somatic nervous system morphology

abnormal lumbar dorsal root ganglion morphology

abnormal sciatic nerve morphology

abnormal myelination

abnormal nervous system electrophysiology

abnormal action potential

abnormal neuron physiology

abnormal synaptic transmission

abnormal CNS synaptic transmission

abnormal excitatory postsynaptic currents

abnormal inhibitory postsynaptic currents

abnormal inhibitory postsynaptic potential

reduced long-term potentiation

increased prepulse inhibition

Availability

Mouse Genotype

Gabbr1^tm1Bet/Gabbr1^tm1Bet

Gabbr1^tm1Pngl/Gabbr1^tm1Pngl

Gabbr1^tm3Bet/Gabbr1^tm3Bet

Gabbr1^tm4Bet/Gabbr1^tm4Bet

Gabbr1^tm1Pngl/Gabbr1⁺

Gabbr1^tm2Bet/Gabbr1^tm2Bet
Tg(HCRT-cre)1Stak/0 (conditional)

Gabbr1^tm2Bet/Gabbr1^tm2Bet
Hdc^{tm1.1(icre)Wwis}/Hdc⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/28/2024 MGI 6.13