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Symbol
Name
ID 		Ppargc1a
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
MGI:1342774
Phenotype annotations related to nervous system
Darker colors indicate more annotations
Human Phenotypes
Dysphagia
Spasticity
Fatigable weakness of bulbar muscles
Fatigable weakness of swallowing muscles
Fatigable weakness of respiratory muscles
Gliosis
Motor neuron atrophy
Amyotrophic lateral sclerosis
Cerebellar atrophy
Neurodegeneration
Neuronal loss in central nervous system
Gait ataxia
Bradykinesia
Chorea
Fasciculations
Paralysis
Babinski sign
Dysarthria
Language impairment
Depression
Emotional lability
Anxiety
Atypical behavior
Personality changes
Agitation
Cognitive impairment
Dementia
Frontotemporal dementia
Sleep abnormality
Hyperreflexia
Jaw hyperreflexia
Seizure
Disease(s) Associated with PPARGC1A
amyotrophic lateral sclerosis
Huntington's disease

Mouse Phenotypes
myoclonus
abnormal brainstem morphology
abnormal substantia nigra morphology
abnormal basal ganglion morphology
abnormal hippocampus morphology
abnormal cerebral cortex morphology
abnormal cerebellum morphology
gliosis
abnormal neuron morphology
decreased dopaminergic neuron number
short photoreceptor inner segment
short photoreceptor outer segment
retina photoreceptor degeneration
neurodegeneration
spongiform encephalopathy
Availability Mouse Genotype
Ppargc1atm1Brsp/Ppargc1atm1Brsp
Ppargc1atm1Dpk/Ppargc1atm1Dpk
Ppargc1atm1Brsp/Ppargc1a+
Ppargc1atm2.1Brsp/Ppargc1atm2.1Brsp  (conditional)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory