Symbol
Name
ID

Lrp8
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
MGI:1340044

Phenotype annotations related to nervous system

Darker colors indicate more annotations

Human Phenotypes	EEG abnormality	Delusion	Schizophrenia	Hallucinations	Negativism	Social and occupational deterioration
Disease(s) Associated with LRP8
schizophrenia

Mouse Phenotypes

abnormal neuronal migration

abnormal brain development

reduced cerebellar foliation

abnormal rostral migratory stream morphology

abnormal lateral ventricle morphology

abnormal dentate gyrus morphology

abnormal hippocampus layer morphology

abnormal hippocampus pyramidal cell layer

abnormal cerebral cortex morphology

abnormal Purkinje cell morphology

small cerebellum

abnormal postnatal subventricular zone morphology

decreased motor neuron number

neuron degeneration

reduced long-term potentiation

Availability

Mouse Genotype

Lrp8^tm1Her/Lrp8^tm1Her

Lrp8^tm2.1Her/Lrp8^tm2.1Her

Lrp8^tm3Her/Lrp8^tm3Her

Lrp8^tm5Her/Lrp8^tm5Her

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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