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Symbol
Name
ID

Trp73
transformation related protein 73
MGI:1336991

Phenotype annotations related to nervous system

Darker colors indicate more annotations

Human Phenotypes	Morphological central nervous system abnormality	Hydrocephalus	Ventriculomegaly	Delayed speech and language development
Disease(s) Associated with TP73
primary ciliary dyskinesia

Mouse Phenotypes

intracranial hemorrhage

intraventricular hemorrhage

increased neuron apoptosis

abnormal vomeronasal organ morphology

abnormal forebrain development

abnormal hippocampus development

abnormal cortical marginal zone morphology

decreased Cajal-Retzius cell number

absent Cajal-Retzius cell

hydrocephaly

non-obstructive hydrocephaly

dilated lateral ventricle

abnormal choroid plexus morphology

abnormal hypothalamus morphology

abnormal hippocampus morphology

abnormal hippocampus CA3 region morphology

abnormal dentate gyrus morphology

abnormal hippocampal mossy fiber morphology

abnormal hippocampus neuron morphology

abnormal cerebral cortex morphology

abnormal dendrite morphology

decreased neuron number

abnormal trigeminal ganglion morphology

neurodegeneration

abnormal cerebrospinal fluid production

Availability

Mouse Genotype

Trp73^tm1(cre)Agof/Trp73^tm1(cre)Agof

Trp73^tm1Fmc/Trp73^tm1Fmc

Trp73^tm1Mak/Trp73^tm1Mak

Trp73^tm2Mak/Trp73^tm2Mak

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/28/2024 MGI 6.13