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Symbol
Name
ID

Aspm
abnormal spindle microtubule assembly
MGI:1334448

Phenotype annotations related to nervous system

Darker colors indicate more annotations

Human Phenotypes

Microcephaly

Ventriculomegaly

Pachygyria

Simplified gyral pattern

Cortical dysplasia

Hypoplasia of the frontal lobes

Small cerebral cortex

Agenesis of corpus callosum

Hypoplasia of the corpus callosum

Cerebellar hypoplasia

Gray matter heterotopia

Delayed speech and language development

Attention deficit hyperactivity disorder

Intellectual disability

Intellectual disability, severe

Hyperreflexia

Global developmental delay

Motor delay

Seizure

Disease(s) Associated with ASPM

primary autosomal recessive microcephaly

primary autosomal recessive microcephaly 5

Mouse Phenotypes		abnormal brain development	decreased brain weight	decreased brain size	enlarged lateral ventricles	abnormal cerebral hemisphere morphology	abnormal neocortex morphology	abnormal barrel cortex morphology	thin cerebral cortex	abnormal astrocyte morphology	decreased neuronal precursor cell number
Availability	Mouse Genotype	abnormal brain development	decreased brain weight	decreased brain size	enlarged lateral ventricles	abnormal cerebral hemisphere morphology	abnormal neocortex morphology	abnormal barrel cortex morphology	thin cerebral cortex	abnormal astrocyte morphology	decreased neuronal precursor cell number
	Aspm^{Gt(AA0137)Wtsi}/Aspm^{Gt(AA0137)Wtsi}
	Aspm^{Gt(AJ0069)Wtsi}/Aspm^{Gt(AJ0069)Wtsi}
	Aspm^tm1(cre)Mrc/Aspm^tm1(cre)Mrc
	Aspm^tm1.2Kxi/Aspm^tm1.2Kxi

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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