Symbol
Name
ID

Hcn2
hyperpolarization-activated, cyclic nucleotide-gated K+ 2
MGI:1298210

Phenotype annotations related to nervous system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Bilateral tonic-clonic seizure	Generalized tonic seizure	Febrile seizure (within the age range of 3 months to 6 years)	Atonic seizure
Disease(s) Associated with HCN2
familial febrile seizures 2

Mouse Phenotypes

nervous system phenotype

increased susceptibility to pharmacologically induced seizures

tonic-clonic seizures

absence seizures

abnormal spike wave discharge

abnormal nervous system electrophysiology

abnormal action potential

abnormal afterhyperpolarization

abnormal summary potential

abnormal neuron physiology

decreased channel response intensity

Availability

Mouse Genotype

Hcn2^ap/Hcn2^ap

Hcn2^tm1.2Lex/Hcn2^tm1.2Lex

Hcn2^tm1Ldw/Hcn2^tm1Ldw

Hcn2^trls/Hcn2^trls

Hcn2^ap/Hcn2⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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