Symbol Name ID |
Atxn2
ataxin 2 MGI:1277223 |
* | Aspects of the system are reported to show a normal phenotype. |
Darker colors indicate more annotations |
Human Phenotypes | Hyposmia |
Orthostatic hypotension due to autonomic dysfunction |
Dysphagia |
Oculomotor apraxia |
Spasticity |
Frequent falls |
Gliosis |
Substantia nigra gliosis |
Dilated fourth ventricle |
Cerebral cortical atrophy |
Lewy bodies |
Cerebellar atrophy |
Olivopontocerebellar atrophy |
Spinocerebellar tract degeneration |
Neuronal loss in central nervous system |
Ataxia |
Dysdiadochokinesis |
Dysmetria |
Limb ataxia |
Progressive cerebellar ataxia |
Bradykinesia |
Parkinsonism |
Parkinsonism with favorable response to dopaminergic medication |
Fasciculations |
Myoclonus |
Tremor |
Action tremor |
Postural tremor |
Resting tremor |
Babinski sign |
Monotonic speech |
Dysarthria |
Depression |
Low frustration tolerance |
Schizophrenia |
Hallucinations |
Visual hallucination |
Apathy |
Personality changes |
Impulsivity |
Agitation |
Mental deterioration |
Dementia |
Micrographia |
Sleep abnormality |
Hyporeflexia |
Akinesia |
Dyskinesia |
Dystonia |
Shuffling gait |
Short stepped shuffling gait |
Unsteady gait |
Postural instability |
Impaired vibratory sensation |
Abnormal autonomic nervous system physiology |
Disease(s) Associated with ATXN2 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
late onset Parkinson's disease | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
spinocerebellar ataxia type 2 |
Mouse Phenotypes | nervous system phenotype |
abnormal Purkinje cell morphology |
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Availability | Mouse Genotype | ||
Atxn2tm1Plt/Atxn2tm1Plt | * | ||
Atxn2tm2.1Aub/Atxn2tm2.1Aub |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/28/2024 MGI 6.13 |
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