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Symbol
Name
ID 		Snca
synuclein, alpha
MGI:1277151
Phenotype annotations related to nervous system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Orthostatic hypotension
Dysphagia
Gliosis
Lewy bodies
Global brain atrophy
Bradykinesia
Parkinsonism
Myoclonus
Resting tremor
Dysarthria
Depression
Paranoia
Delusion
Hallucinations
Visual hallucination
Mental deterioration
Dementia
Micrographia
Fluctuations in consciousness
Sleep abnormality
Hypokinesia
Dystonia
Gait disturbance
Loss of ambulation
Shuffling gait
Postural instability
Abnormal autonomic nervous system physiology
Disease(s) Associated with SNCA
Lewy body dementia
Parkinson's disease 1
Parkinson's disease 4

Mouse Phenotypes
nervous system phenotype
decreased susceptibility to dopaminergic neuron neurotoxicity
microgliosis
abnormal brainstem morphology
astrocytosis
abnormal neuron morphology
abnormal dopaminergic neuron morphology
decreased dopaminergic neuron number
abnormal motor neuron morphology
abnormal axon morphology
abnormal dendrite morphology
abnormal neuromuscular synapse morphology
abnormal spinal cord morphology
alpha-synuclein inclusion body
axon degeneration
demyelination
abnormal synaptic transmission
reduced long-term potentiation
abnormal miniature excitatory postsynaptic currents
Availability Mouse Genotype
Sncatm1Rosl/Sncatm1Rosl *
Sncatm1Sud/Sncatm1Sud
Sncatm1Wtd/Sncatm1Wtd
Tg(THY1-Snca)M1mSud/0 *
Tg(Thy1-Snca)1S13Putt/?
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/21/2024
MGI 6.23 		The Jackson Laboratory