|
Symbol Name ID |
Phox2b
paired-like homeobox 2b MGI:1100882 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Aganglionic megacolon |
Horner syndrome |
Ganglioneuroma |
Spinal cord compression |
Neoplasm of the central nervous system |
Neuroblastoma |
Ganglioneuroblastoma |
Neoplasm of the nervous system |
Ataxia |
Myoclonus |
Irritability |
Cognitive impairment |
Antalgic gait |
Seizure |
Abnormality of the autonomic nervous system |
Abnormal autonomic nervous system physiology |
| Disease(s) Associated with PHOX2B | ||||||||||||||||
| congenital central hypoventilation syndrome | ||||||||||||||||
| neuroblastoma |
| Mouse Phenotypes | nervous system phenotype |
abnormal neuron differentiation |
impaired neuron differentiation |
abnormal neuronal precursor proliferation |
decreased enteric neural crest cell number |
abnormal nervous system morphology |
abnormal autonomic nervous system morphology |
abnormal enteric nervous system morphology |
abnormal enteric ganglia morphology |
abnormal parasympathetic ganglion morphology |
abnormal ciliary ganglion morphology |
abnormal pterygopalatine ganglion morphology |
abnormal sympathetic ganglion morphology |
abnormal brain interneuron morphology |
abnormal area postrema morphology |
abnormal medulla oblongata morphology |
abnormal retrotrapezoid nucleus morphology |
abnormal trigeminal V mesencephalic nucleus morphology |
small facial motor nucleus |
abnormal locus ceruleus morphology |
abnormal glial cell morphology |
abnormal innervation |
abnormal neuron morphology |
abnormal motor neuron morphology |
decreased neuronal precursor cell number |
abnormal cranial ganglia morphology |
abnormal geniculate ganglion morphology |
abnormal glossopharyngeal ganglion morphology |
abnormal petrosal ganglion morphology |
absent petrosal ganglion |
small trigeminal ganglion |
abnormal vagus ganglion morphology |
abnormal nodose ganglion morphology |
abnormal cranial nerve morphology |
abnormal facial nerve morphology |
absent facial nerve |
absent trigeminal nerve |
abnormal vagus nerve morphology |
abnormal autonomic nervous system physiology |
abnormal nervous system electrophysiology |
abnormal neuron physiology |
|
| Availability | Mouse Genotype | |||||||||||||||||||||||||||||||||||||||||
| Phox2btm1(Phox2a)Mist/Phox2btm1(Phox2a)Mist | ||||||||||||||||||||||||||||||||||||||||||
| Phox2btm1Jbr/Phox2btm1Jbr | ||||||||||||||||||||||||||||||||||||||||||
| Phox2bDilp1/Phox2b+ | ||||||||||||||||||||||||||||||||||||||||||
| Phox2btm1.1Heno/Phox2b+ | ||||||||||||||||||||||||||||||||||||||||||
| Phox2btm1Jbr/Phox2b+ | ||||||||||||||||||||||||||||||||||||||||||
| Phox2btm2.1Heno/Phox2b+ | ||||||||||||||||||||||||||||||||||||||||||
| Phox2btm2Jbr/Phox2b+ | ||||||||||||||||||||||||||||||||||||||||||
| Phox2btm3.1Jbr/Phox2btm3.1Jbr Tg(Pou3f4-cre)32Cren/0 (conditional) |
* | |||||||||||||||||||||||||||||||||||||||||
| Phox2btm3.1Jbr/Phox2btm3.1Jbr Isl1tm1(cre)Tmj/Isl1+ (conditional) |
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| Phox2btm3.1Jbr/Phox2btm3.1Jbr Egr2tm2(cre)Pch/Egr2+ (conditional) |
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| Phox2btm3.1Jbr/Phox2btm3.1Jbr H2az2Tg(Wnt1-cre)11Rth/H2az2+ (conditional) |
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| Isl1tm1(cre)Tmj/Isl1+ Phox2btm3.1Jbr/Phox2btm3.1Jbr (conditional) |
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| Egr2tm2(cre)Pch/Egr2+ Phox2btm4Jbr/Phox2b+ (conditional) |
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| Phox2btm1Rth/Phox2b+ Hprt1tm1(CAG-cre)Mnn/? (conditional) |
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| Phox2btm1Rth/Phox2b+ Tg(Fabp7-cre,-lacZ)3Gtm/0 (conditional) |
* | |||||||||||||||||||||||||||||||||||||||||
| Phox2btm4Jbr/Phox2b+ Tg(Pgk1-cre)1Lni/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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