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Symbol
Name
ID

Kif5a
kinesin family member 5A
MGI:109564

Phenotype annotations related to nervous system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Ankle clonus

Lower limb spasticity

Spastic paraplegia

Upper limb spasticity

Spastic gait

Spastic paraparetic gait

Amyotrophic lateral sclerosis

Peripheral axonal neuropathy

Ataxia

Parkinsonism

Knee clonus

Upper motor neuron dysfunction

Babinski sign

Cognitive impairment

Intellectual disability, moderate

Hyperreflexia in upper limbs

Lower limb hyperreflexia

Sensorimotor neuropathy

Paresthesia

Distal sensory impairment

Impaired distal vibration sensation

Impaired vibration sensation in the lower limbs

Disease(s) Associated with KIF5A

amyotrophic lateral sclerosis type 25

hereditary spastic paraplegia 10

Mouse Phenotypes		nervous system phenotype	seizures	sporadic seizures	abnormal motor neuron morphology	axon degeneration	abnormal axonal transport	abnormal GABA-mediated receptor currents	decreased miniature inhibitory postsynaptic current amplitude
Availability	Mouse Genotype	nervous system phenotype	seizures	sporadic seizures	abnormal motor neuron morphology	axon degeneration	abnormal axonal transport	abnormal GABA-mediated receptor currents
	Kif5a^tm1Gsn/Kif5a^tm1Gsn	*
	Kif5a^tm1.2Noh/Kif5a^tm1.2Noh Tg(Syn1-cre)671Jxm/0 (conditional)	*
	Kif5a^tm1Gsn/Kif5a^tm2Gsn Tg(Syn1-cre)671Jxm/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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