Symbol
Name
ID

Dab1
disabled 1
MGI:108554

Phenotype annotations related to nervous system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Dysphagia	Frequent falls	Cerebellar atrophy	Ataxia	Tremor	Dysarthria	Unsteady gait
Disease(s) Associated with DAB1
spinocerebellar ataxia type 37

Mouse Phenotypes

nervous system phenotype

abnormal neuronal migration

abnormal neuronal precursor cell migration

abnormal nervous system morphology

abnormal brain morphology

abnormal telencephalon development

abnormal cortical marginal zone morphology

abnormal subplate morphology

absent subplate

abnormal cerebellar foliation

absent cerebellar foliation

abnormal rostral migratory stream morphology

abnormal hippocampus morphology

abnormal hippocampus CA2 region morphology

abnormal dentate gyrus morphology

abnormal hippocampus layer morphology

abnormal hippocampus pyramidal cell layer

abnormal hippocampus pyramidal cell morphology

abnormal cerebral cortex morphology

abnormal neocortex morphology

abnormal stratification in cerebral cortex

abnormal olfactory bulb morphology

abnormal olfactory bulb granule cell layer morphology

abnormal cerebellum morphology

abnormal cerebellar layer morphology

abnormal cerebellar Purkinje cell layer

ectopic Purkinje cell

abnormal cerebellar granule layer morphology

small cerebellum

cerebellum hypoplasia

abnormal postnatal subventricular zone morphology

abnormal retina rod bipolar cell morphology

Availability

Mouse Genotype

Dab1^scm-3J/Dab1^scm-3J

Dab1^scm-4J/Dab1^scm-4J

Dab1^scm-5J/Dab1^scm-5J

Dab1^scm-6J/Dab1^scm-6J

Dab1^scm/Dab1^scm

Dab1^tm1.1Bwh/Dab1^tm1.1Bwh

Dab1^tm1Bwh/Dab1^tm1Bwh

Dab1^tm1Cpr/Dab1^tm1Cpr

Dab1^tm2Cpr/Dab1^tm2Cpr

Dab1^tm3.1Cpr/Dab1^tm3.1Cpr

Dab1^tm5Cpr/Dab1^tm5Cpr

Dab1^tm6Cpr/Dab1^tm6Cpr

Dab1^tm1Bwh/Dab1⁺

Dab1^tm1Cpr/Dab1^tm3.1Cpr

Dab1^tm1Cpr/Dab1^tm4Cpr

Dab1^tm1Cpr/Dab1^tm6Cpr

Dab1^tm5Cpr/Dab1^tm6Cpr

Dab1^tm1.1Mull/Dab1^tm1.1Mull
Tg(Nes-cre)1Kln/0 (conditional)

Dab1^tm1.1Mull/Dab1^tm1.1Mull
Neurod6^tm1(cre)Kan/Neurod6⁺ (conditional)

Dab1^tm1.1Mull/Dab1^tm1.1Mull
Cux2^{tm2.1(cre)Mull}/Cux2⁺ (conditional)

Dab1^tm1.1Mull/Dab1^tm1.1Mull (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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