Symbol Name ID |
Tfam
transcription factor A, mitochondrial MGI:107810 |
Darker colors indicate more annotations |
Human Phenotypes | Dysphagia |
Spasticity |
Fatigable weakness of bulbar muscles |
Fatigable weakness of swallowing muscles |
Fatigable weakness of respiratory muscles |
Gliosis |
Motor neuron atrophy |
Amyotrophic lateral sclerosis |
Cerebellar atrophy |
Neurodegeneration |
Neuronal loss in central nervous system |
Gait ataxia |
Bradykinesia |
Chorea |
Fasciculations |
Paralysis |
Babinski sign |
Dysarthria |
Language impairment |
Depression |
Emotional lability |
Anxiety |
Atypical behavior |
Lethargy |
Personality changes |
Agitation |
Cognitive impairment |
Dementia |
Frontotemporal dementia |
Sleep abnormality |
Hyperreflexia |
Jaw hyperreflexia |
Seizure |
Disease(s) Associated with TFAM | |||||||||||||||||||||||||||||||||
amyotrophic lateral sclerosis | |||||||||||||||||||||||||||||||||
Huntington's disease | |||||||||||||||||||||||||||||||||
mitochondrial DNA depletion syndrome 15 |
Mouse Phenotypes | decreased neuron mitochondrial DNA content |
abnormal enteric neuron morphology |
abnormal PNS glial cell morphology |
gliosis |
abnormal dopaminergic neuron morphology |
loss of dopaminergic neurons |
decreased neuron number |
neuron degeneration |
neuronal intranuclear inclusions |
absent optic nerve |
neurodegeneration |
axon degeneration |
abnormal nervous system physiology |
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Availability | Mouse Genotype | |||||||||||||
Tfamtm1.1Lrsn/Tfamtm1.1Lrsn | ||||||||||||||
Tfamtm1Lrsn/Tfamtm1Lrsn Tg(Camk2a-cre)1Lfr/0 (conditional) |
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Slc6a3tm1(cre)Lrsn/Slc6a3+ Tfamtm1Lrsn/Tfamtm1Lrsn (conditional) |
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Cnptm1(cre)Kan/Cnp+ Tfamtm1Lrsn/Tfamtm1Lrsn (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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