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Symbol Name ID |
Gdnf
glial cell line derived neurotrophic factor MGI:107430 |
| Darker colors indicate more annotations |
| Human Phenotypes | Aganglionic megacolon |
Intellectual disability |
| Disease(s) Associated with GDNF | ||
| Hirschsprung's disease |
| Mouse Phenotypes | abnormal muscle spindle morphology |
abnormal enteric nervous system morphology |
abnormal enteric ganglia morphology |
abnormal enteric neuron morphology |
abnormal enteric cholinergic neuron morphology |
absent enteric neurons |
abnormal myenteric nerve plexus morphology |
abnormal submucous nerve plexus morphology |
abnormal superior cervical ganglion morphology |
abnormal brain morphology |
abnormal substantia nigra morphology |
abnormal tegmentum morphology |
abnormal locus ceruleus morphology |
abnormal dorsal striatum morphology |
abnormal ventral striatum morphology |
abnormal innervation pattern to muscle |
abnormal motor neuron innervation pattern |
abnormal cholinergic neuron morphology |
decreased motor neuron number |
abnormal cranial ganglia morphology |
small dorsal root ganglion |
abnormal spinal nerve morphology |
abnormal spinal cord lateral motor column morphology |
abnormal neurotransmitter secretion |
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| Availability | Mouse Genotype | ||||||||||||||||||||||||
| Gdnftm1Bbd/Gdnftm1Bbd | |||||||||||||||||||||||||
| Gdnftm1Lmgd/Gdnftm1Lmgd | |||||||||||||||||||||||||
| Gdnftm1Rosl/Gdnftm1Rosl | |||||||||||||||||||||||||
| Gdnftm2Bbd/Gdnftm2Bbd | |||||||||||||||||||||||||
| Gdnftm1Lmgd/Gdnf+ | |||||||||||||||||||||||||
| Gdnftm1Rosl/Gdnf+ | |||||||||||||||||||||||||
| Gdnftm1.1Neas/Gdnftm1.1Neas Egr3tm1(cre)Mod/Egr3tm1(cre)Mod (conditional) |
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| Gdnftm1.1Neas/Gdnftm1.1Neas Myf5tm3(cre)Sor/Myf5+ (conditional) |
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| Gdnftm1Bbd/Gdnftm1.1Neas Egr3tm1(cre)Mod/Egr3+ (conditional) |
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| Gdnftm1Bbd/Gdnftm1Jlob Tg(CAG-cre/Esr1*)5Amc/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/21/2024 MGI 6.23 |
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