Symbol
Name
ID

Zic3
zinc finger protein of the cerebellum 3
MGI:106676

Phenotype annotations related to nervous system

Darker colors indicate more annotations

Human Phenotypes	Microcephaly	Aqueductal stenosis	Hydrocephalus	Agenesis of corpus callosum	Cerebral atrophy	Cerebellar hypoplasia	Cerebellar atrophy	Myelomeningocele
Disease(s) Associated with ZIC3	Microcephaly	Aqueductal stenosis	Hydrocephalus	Agenesis of corpus callosum	Cerebral atrophy	Cerebellar hypoplasia	Cerebellar atrophy	Myelomeningocele
situs inversus
visceral heterotaxy
X-linked VACTERL association

Mouse Phenotypes

abnormal neural plate morphology

abnormal neural tube morphology

abnormal embryonic neuroepithelial layer differentiation

delayed neural tube closure

open neural tube

abnormal midbrain morphology

abnormal forebrain morphology

abnormal basal ganglion morphology

abnormal diencephalon morphology

disorganized thalamus

abnormal hippocampus morphology

abnormal cerebral cortex morphology

abnormal cerebellar hemisphere morphology

abnormal cerebellum vermis lobule III morphology

abnormal cerebellum vermis lobule V morphology

cerebellum vermis hypoplasia

absent cerebellum

anencephaly

exencephaly

abnormal olfactory nerve morphology

Availability

Mouse Genotype

Zic3^Bn/Zic3^Bn

Zic3^tm1Bca/Zic3^tm1Bca

Zic3^tm1Bca/Zic3⁺

Zic3^tm1Bca/Y

Zic3^Bn/0

Zic3^tm2.1Jwb/Y
Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ (conditional)

Zic3^tm1.1Smwa/Y
Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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