Symbol
Name
ID

Myo7a
myosin VIIA
MGI:104510

Phenotype annotations related to nervous system

Darker colors indicate more annotations

Human Phenotypes

Encephalocele

Cerebral cortical atrophy

Subcortical cerebral atrophy

Aplasia/Hypoplasia of the cerebellar vermis

Aplasia/Hypoplasia of the cerebellum

Abnormality of neuronal migration

Ataxia

Hemiplegia/hemiparesis

Depression

Anxiety

Psychosis

Schizophrenia

Hallucinations

Hyperacusis

Cognitive impairment

Intellectual disability

Global developmental delay

Motor delay

Seizure

Disease(s) Associated with MYO7A

Leber congenital amaurosis

Usher syndrome

Usher syndrome type 1

Mouse Phenotypes

abnormal cochlear hair cell morphology

decreased cochlear outer hair cell number

abnormal cochlear hair cell stereociliary bundle morphology

abnormal cochlear hair cell inter-stereocilial links morphology

absent cochlear hair bundle ankle links

abnormal inner hair cell stereociliary bundle morphology

abnormal orientation of inner hair cell stereociliary bundles

decreased inner hair cell stereocilia number

fused inner hair cell stereocilia

abnormal orientation of cochlear hair cell stereociliary bundles

abnormal orientation of outer hair cell stereociliary bundles

abnormal outer hair cell stereociliary bundle morphology

decreased outer hair cell stereocilia number

short cochlear hair cell stereocilia

abnormal cochlear outer hair cell morphology

abnormal cochlear OHC efferent innervation pattern

cochlear outer hair cell degeneration

short cochlear outer hair cells

cochlear hair cell degeneration

abnormal hair cell morphology

abnormal vestibular hair cell stereociliary bundle morphology

decreased vestibular hair cell stereocilia number

absent cochlear microphonics

abnormal cochlear nerve compound action potential

increased cochlear nerve compound action potential

gliosis

abnormal retina rod cell morphology

retina rod cell degeneration

cochlear ganglion degeneration

vestibular ganglion hypoplasia

Availability

Mouse Genotype

Myo7a^26SB/Myo7a^26SB

Myo7a^816SB/Myo7a^816SB

Myo7a^3336SB/Myo7a^3336SB

Myo7a^4494SB/Myo7a^4494SB

Myo7a^4626SB/Myo7a^4626SB

Myo7a^dmbo2/Myo7a^dmbo2

Myo7a^ewaso/Myo7a^ewaso

Myo7a^Hdb/Myo7a^Hdb

Myo7a^polka/Myo7a^polka

Myo7a^sh1-8J/Myo7a^sh1-8J

Myo7a^sh1-11J/Myo7a^sh1-11J

Myo7a^sh1/Myo7a^sh1

Myo7a^{tm1b(EUCOMM)Wtsi}/Myo7a^{tm1b(EUCOMM)Wtsi}

Myo7a^4626SB/Myo7a⁺

Myo7a^Hdb/Myo7a^4626SB

Myo7a^Hdb/Myo7a⁺

Myo7a^{tm1b(EUCOMM)Wtsi}/Myo7a⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/21/2024 MGI 6.23