Symbol
Name
ID

Cdk5
cyclin dependent kinase 5
MGI:101765

Phenotype annotations related to nervous system

Darker colors indicate more annotations

Human Phenotypes	Microcephaly	Lissencephaly	Agyria	Agenesis of corpus callosum	Cerebellar hypoplasia	EEG with burst suppression	Areflexia	Global developmental delay	Persistent head lag	Seizure
Disease(s) Associated with CDK5
lissencephaly 7 with cerebellar hypoplasia

Mouse Phenotypes

abnormal brain development

abnormal hippocampus development

abnormal cortical plate morphology

abnormal cerebellum development

abnormal cerebellar foliation

abnormal olfactory bulb development

abnormal dentate gyrus morphology

abnormal hippocampus layer morphology

abnormal cerebral cortex morphology

abnormal stratification in cerebral cortex

abnormal cerebellar cortex morphology

abnormal motor neuron morphology

chromatolysis

abnormal facial nerve morphology

abnormal hypoglossal nerve morphology

abnormal spinal cord ventral horn morphology

abnormal synaptic plasticity

abnormal excitatory postsynaptic currents

abnormal excitatory postsynaptic potential

abnormal long-term potentiation

increased post-tetanic potentiation

Availability

Mouse Genotype

Cdk5^tm1Kul/Cdk5^tm1Kul

Cdk5^tm1Bibb/Cdk5^tm1Bibb
Tg(Prnp-cre/ERT)28.4Ics/0 (conditional)

Cdk5^tm2Kul/Cdk5^tm2Kul
Tg(Nefh-cre)12Kul/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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