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Symbol
Name
ID

Prf1
perforin 1 (pore forming protein)
MGI:97551

Phenotype annotations related to neoplasm

!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes	Lymphoma
Disease(s) Associated with PRF1	Lymphoma
non-Hodgkin lymphoma

Mouse Phenotypes		increased T cell derived lymphoma incidence	abnormal tumor morphology	increased tumor growth/size	increased lymphoma incidence	increased B cell derived lymphoma incidence	increased lung adenocarcinoma incidence	increased sarcoma incidence	increased incidence of induced tumors	decreased tumor latency	increased tumor latency
Availability	Mouse Genotype	increased T cell derived lymphoma incidence	abnormal tumor morphology	increased tumor growth/size	increased lymphoma incidence	increased B cell derived lymphoma incidence	increased lung adenocarcinoma incidence	increased sarcoma incidence	increased incidence of induced tumors	decreased tumor latency	increased tumor latency
	Prf1^tm1Sdz/Prf1^tm1Sdz									!
	Prf1^tm1Tsc/Prf1^tm1Tsc
	Prf1^tm1Sdz/Prf1⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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