|
Symbol Name ID |
Nf2
neurofibromin 2 MGI:97307 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Lisch nodules |
Retinal hamartoma |
Hereditary nonpolyposis colorectal carcinoma |
Neoplasm of the stomach |
Hepatocellular carcinoma |
Gastrointestinal stroma tumor |
Vestibular schwannoma |
Bilateral vestibular schwannoma |
Unilateral vestibular schwannoma |
Uterine leiomyosarcoma |
Renal cell carcinoma |
Transitional cell carcinoma of the bladder |
Neoplasm of the skin |
Neurofibroma |
Peripheral schwannoma |
Astrocytoma |
Glioma |
Ependymoma |
Neuroma |
Meningioma |
Intracranial meningioma |
Optic nerve sheath meningioma |
Spinal meningioma |
Spinal cord tumor |
| Disease(s) Associated with NF2 | ||||||||||||||||||||||||
| colorectal cancer | ||||||||||||||||||||||||
| gastrointestinal stromal tumor | ||||||||||||||||||||||||
| hepatocellular carcinoma | ||||||||||||||||||||||||
| vestibular schwannomatosis |
| Mouse Phenotypes | neoplasm |
increased fibroadenoma incidence |
increased pituitary adenoma incidence |
increased hepatobiliary system tumor incidence |
increased hepatocellular carcinoma incidence |
osseous metaplasia |
increased neurofibroma incidence |
increased hamartoma incidence |
increased lymphoma incidence |
increased malignant tumor incidence |
increased carcinoma incidence |
increased lung adenocarcinoma incidence |
increased renal carcinoma incidence |
increased sarcoma incidence |
increased fibrosarcoma incidence |
increased neurofibrosarcoma incidence |
increased extremity angiosarcoma incidence |
increased odontosarcoma incidence |
increased osteosarcoma incidence |
increased mesothelioma incidence |
increased odontoma incidence |
increased Schwannoma incidence |
increased meningioma incidence |
increased osteoma incidence |
increased tumor incidence |
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| Availability | Mouse Genotype | |||||||||||||||||||||||||
| Nf2tm1Gth/Nf2+ | * | |||||||||||||||||||||||||
| Nf2tm1Tyj/Nf2+ | * | |||||||||||||||||||||||||
| Nf2tm2.1Gth/Nf2+ | * | |||||||||||||||||||||||||
| Nf2tm2Gth/Nf2tm2Gth Tg(Mpz-cre)1Brn/0 (conditional) |
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| Nf2tm2Gth/Nf2tm2Gth Tg(Mpz-cre)2Brn/0 (conditional) |
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| Nf2tm2Gth/Nf2tm2Gth Tg(Mpz-cre)3Brn/0 (conditional) |
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| Nf2tm2Gth/Nf2tm2Gth Tg(Mpz-cre)4Brn/0 (conditional) |
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| Nf2tm2Gth/Nf2tm2Gth Tg(Mpz-cre)#Brn/0 (conditional) |
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| Nf2tm2Gth/Nf2tm2Gth (conditional) | ||||||||||||||||||||||||||
| Nf2tm2Gth/Nf2tm2Gth Tg(Vil1-cre)20Syr/0 (conditional) |
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| Nf2tm2Gth/Nf2tm2Gth Tg(Mx1-cre)1Cgn/0 (conditional) |
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| Nf2tm2Gth/Nf2tm2Gth Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ (conditional) |
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| Nf2tm2Gth/Nf2tm2Gth Ptgdstm1.1(cre)Gvn/Ptgds+ (conditional) |
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| Nf2tm2Gth/Nf2tm2Gth Tg(Postn-cre)1Sjc/0 (conditional) |
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| Nf2tm2Gth/Nf2tm2Gth Tg(TPO-cre)1Shk/0 (conditional) |
* | |||||||||||||||||||||||||
| Nf2tm1Gth/Nf2tm2Gth Tg(Mpz-cre)1Brn/0 (conditional) |
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| Nf2tm1Gth/Nf2tm2Gth Tg(Mpz-cre)#Brn/0 (conditional) |
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| Nf2tm2Gth/Nf2+ Tg(Mpz-cre)#Brn/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/28/2024 MGI 6.13 |
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