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Symbol Name ID |
Pik3ca
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha MGI:1206581 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Breast carcinoma |
Hereditary nonpolyposis colorectal carcinoma |
Hamartomatous polyposis |
Neoplasm of the stomach |
Stomach cancer |
Hepatocellular carcinoma |
Thyroid adenoma |
Dysgerminoma |
Ovarian papillary adenocarcinoma |
Uterine leiomyosarcoma |
Nephroblastoma |
Renal cell carcinoma |
Transitional cell carcinoma of the bladder |
Subcutaneous lipoma |
Seborrheic keratosis |
Lipoma |
Meningioma |
Alveolar cell carcinoma |
Non-small cell lung carcinoma |
Lung adenocarcinoma |
| Disease(s) Associated with PIK3CA | ||||||||||||||||||||
| breast cancer | ||||||||||||||||||||
| CLOVES syndrome | ||||||||||||||||||||
| colorectal cancer | ||||||||||||||||||||
| Cowden syndrome 5 | ||||||||||||||||||||
| hepatocellular carcinoma | ||||||||||||||||||||
| lung cancer | ||||||||||||||||||||
| ovarian cancer | ||||||||||||||||||||
| seborrheic keratosis | ||||||||||||||||||||
| stomach cancer |
| Mouse Phenotypes | neoplasm |
increased mammary gland tumor incidence |
increased fibroadenoma incidence |
increased mammary adenocarcinoma incidence |
increased mammary adenoacanthoma incidence |
increased pancreatic ductal adenocarcinoma incidence |
increased pancreatic intraepithelial neoplasia incidence |
increased prostate intraepithelial neoplasia incidence |
decreased incidence of tumors by chemical induction |
increased classified tumor incidence |
increased carcinoma incidence |
increased sarcoma incidence |
increased osteosarcoma incidence |
increased tumor incidence |
|
| Availability | Mouse Genotype | ||||||||||||||
| Pik3catm1Jdo/Pik3catm1Jdo | |||||||||||||||
| Pik3catm1Gilb/Pik3ca+ | * | ||||||||||||||
| Tg(Amhr2-Pik3ca*,-GFP)#Lzh/0 | * | ||||||||||||||
| Pik3catm1Jjz/Pik3catm1Jjz Tg(Pbsn-cre)4Prb/0 (conditional) |
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| Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+ Tg(MMTV-cre)1Mam/0 (conditional) |
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| Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+ Tg(MMTV-cre)#Tfln/0 (conditional) |
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| Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+ (conditional) | * | ||||||||||||||
| Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+ Olig2tm1.1(cre)Wdr/Olig2+ (conditional) |
* | ||||||||||||||
| Gt(ROSA)26Sortm2(Pik3ca*)Dsa/Gt(ROSA)26Sor+ Ptf1atm1(cre)Hnak/Ptf1a+ (conditional) |
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| Gt(ROSA)26Sortm2(Pik3ca*)Dsa/Gt(ROSA)26Sor+ Tg(Cela1-cre/ERT)1Dam/0 (conditional) |
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| Gt(ROSA)26Sortm7(Pik3ca*,EGFP)Rsky/Gt(ROSA)26Sor+ Tg(CAG-cre/Esr1*)5Amc/0 (conditional) |
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| Pik3catm1.1Waph/Pik3ca+ Tg(MMTV-cre)#Mam/0 (conditional) |
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| Pik3catm1Gne/Pik3ca+ Tg(MMTV-cre)1Mam/0 (conditional) |
* | ||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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