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Symbol
Name
ID 		Smad3
SMAD family member 3
MGI:1201674
Phenotype annotations related to neoplasm
!Indicates phenotype varies with strain background.
Darker colors indicate more annotations
Human Phenotypes
Hematological neoplasm
Adenoma sebaceum
Salivary gland neoplasm
Breast carcinoma
Neoplasm of the rectum
Colon cancer
Intestinal polyposis
Neoplasm of the stomach
Neoplasm of the liver
Hepatocellular carcinoma
Neoplasm of the pancreas
Pancreatic adenocarcinoma
Pituitary adenoma
Neoplasm of the thyroid gland
Ovarian neoplasm
Ovarian carcinoma
Endometrial carcinoma
Renal neoplasm
Malignant genitourinary tract tumor
Urinary tract neoplasm
Neoplasm of the skin
Basal cell carcinoma
Neoplasm of the skeletal system
Glioblastoma multiforme
Benign neoplasm of the central nervous system
Neuroblastoma
Laryngeal carcinoma
Melanoma
Disease(s) Associated with SMAD3
Lynch syndrome
pancreatic cancer

Mouse Phenotypes
increased intestinal adenocarcinoma incidence
increased metastatic potential
Availability Mouse Genotype
Smad3tm1Cxd/Smad3tm1Cxd
Smad3tm1Par/Smad3tm1Par !
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/28/2024
MGI 6.13 		The Jackson Laboratory