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Symbol Name ID |
Ppargc1a
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha MGI:1342774 |
| Darker colors indicate more annotations |
| Human Phenotypes | Foot dorsiflexor weakness |
Lower limb muscle weakness |
Upper limb muscle weakness |
Rigidity |
Spasticity |
Muscle spasm |
Fatigable weakness of bulbar muscles |
Fatigable weakness of swallowing muscles |
Fatigable weakness of respiratory muscles |
Generalized muscle weakness |
Skeletal muscle atrophy |
Progressive distal muscular atrophy |
Progressive spinal muscular atrophy |
| Disease(s) Associated with PPARGC1A | |||||||||||||
| amyotrophic lateral sclerosis | |||||||||||||
| Huntington's disease |
| Mouse Phenotypes | dystonia |
myoclonus |
abnormal myocardial fiber morphology |
decreased cardiac muscle contractility |
decreased ventricle muscle contractility |
cardiomyopathy |
decreased gastrocnemius weight |
decreased soleus weight |
abnormal skeletal muscle fiber morphology |
decreased skeletal muscle weight |
abnormal skeletal muscle morphology |
abnormal muscle physiology |
increased muscle fatigability |
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| Availability | Mouse Genotype | |||||||||||||
| Ppargc1atm1Brsp/Ppargc1atm1Brsp | ||||||||||||||
| Ppargc1atm1Dpk/Ppargc1atm1Dpk | ||||||||||||||
| Tg(Ckm-Ppargc1a)31Brsp/0 | ||||||||||||||
| Tg(Myh6-rtTA)8585Jam/0 Tg(tetO-Ppargc1a)1Dpk/0 |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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