Symbol Name ID |
Dnm2
dynamin 2 MGI:109547 |
Darker colors indicate more annotations |
Human Phenotypes | Facial palsy |
Distal lower limb muscle weakness |
Proximal upper limb amyotrophy |
Proximal muscle weakness in upper limbs |
Flexion contracture |
Generalized hypotonia |
EMG: positive sharp waves |
EMG: myopathic abnormalities |
EMG: myotonic discharges |
Easy fatigability |
Distal muscle weakness |
Proximal muscle weakness |
Type 1 muscle fiber predominance |
Centrally nucleated skeletal muscle fibers |
Distal amyotrophy |
Proximal amyotrophy |
Skeletal muscle hypertrophy |
Disease(s) Associated with DNM2 | |||||||||||||||||
centronuclear myopathy 1 | |||||||||||||||||
Charcot-Marie-Tooth disease dominant intermediate B |
Mouse Phenotypes | abnormal skeletal muscle fiber morphology |
decreased skeletal muscle fiber size |
decreased skeletal muscle fiber diameter |
increased skeletal muscle fiber size |
centrally nucleated skeletal muscle fibers |
decreased skeletal muscle weight |
abnormal skeletal muscle fiber type ratio |
decreased skeletal muscle mass |
increased skeletal muscle mass |
muscular atrophy |
abnormal muscle contractility |
abnormal muscle electrophysiology |
muscle weakness |
myopathy |
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Availability | Mouse Genotype | ||||||||||||||
Dnm2tm1.1Ics/Dnm2tm1.1Ics | |||||||||||||||
Dnm2tm4.1Ics/Dnm2tm4.1Ics | |||||||||||||||
Dnm2tm1.1Ics/Dnm2+ | |||||||||||||||
Dnm2tm2.1Ics/Dnm2+ | |||||||||||||||
Dnm2tm4.1Ics/Dnm2+ |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/28/2024 MGI 6.13 |
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