Symbol
Name
ID

Hnrnpa1
heterogeneous nuclear ribonucleoprotein A1
MGI:104820

Phenotype annotations related to muscle

Darker colors indicate more annotations

Human Phenotypes

Amyotrophy of ankle musculature

Intrinsic hand muscle atrophy

Weakness of the intrinsic hand muscles

Foot dorsiflexor weakness

Proximal muscle weakness in lower limbs

Limb-girdle muscular dystrophy

Joint contracture of the hand

Spastic paraparesis

EMG: myopathic abnormalities

Difficulty walking

Abdominal wall muscle weakness

Distal muscle weakness

Progressive distal muscle weakness

Progressive proximal muscle weakness

Late-onset proximal muscle weakness

Increased variability in muscle fiber diameter

Centrally nucleated skeletal muscle fibers

Increased endomysial connective tissue

Muscle fiber inclusion bodies

Rimmed vacuoles

Distal amyotrophy

Fatty replacement of skeletal muscle

Muscular dystrophy

Myopathy

Disease(s) Associated with HNRNPA1

amyotrophic lateral sclerosis type 20

distal myopathy 3

inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 3

tropical spastic paraparesis

Mouse Phenotypes		dilated cardiomyopathy	abnormal tongue muscle morphology	tongue muscle hypoplasia	abnormal intercostal muscle morphology
Availability	Mouse Genotype
	Hnrnpa1^tm1.1Cyf/Hnrnpa1^tm1.1Cyf

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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