Symbol
Name
ID

Lipa
lysosomal acid lipase A
MGI:96789

Phenotype annotations related to liver/biliary system

Darker colors indicate more annotations

Human Phenotypes	Hepatic steatosis	Portal hypertension	Hepatosplenomegaly	Hepatomegaly	Increased hepatic echogenicity	Cirrhosis	Hepatic fibrosis	Hepatic bridging fibrosis	Periportal fibrosis	Jaundice
Disease(s) Associated with LIPA	Hepatic steatosis	Portal hypertension	Hepatosplenomegaly	Hepatomegaly	Increased hepatic echogenicity	Cirrhosis	Hepatic fibrosis	Hepatic bridging fibrosis	Periportal fibrosis	Jaundice
cholesterol ester storage disease
Wolman disease

Mouse Phenotypes

abnormal liver sinusoid morphology

abnormal Kupffer cell morphology

enlarged liver

hepatosplenomegaly

increased liver weight

increased liver cholesterol level

decreased liver triglyceride level

increased liver triglyceride level

liver inflammation

abnormal liver morphology

abnormal hepatocyte morphology

hepatic steatosis

liver fibrosis

pale liver

Availability

Mouse Genotype

Lipa^tm1Ggb/Lipa^tm1Ggb

Lipa^{tm1c(EUCOMM)Hmgu}/Lipa^{tm1c(EUCOMM)Hmgu}
Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1^{Tg(Alb-cre)21Mgn} (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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