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Symbol
Name
ID 		Pten
phosphatase and tensin homolog
MGI:109583
Phenotype annotations related to liver/biliary system
Darker colors indicate more annotations
Human Phenotypes
Hepatic steatosis
Hepatomegaly
Disease(s) Associated with PTEN
macrocephaly-autism syndrome

Mouse Phenotypes
abnormal liver sinusoid morphology
increased hepatocyte apoptosis
increased hepatocyte proliferation
bile duct hyperplasia
enlarged liver
increased liver weight
increased liver glycogen level
increased liver cholesterol level
increased liver triglyceride level
liver inflammation
abnormal liver morphology
abnormal hepatocyte morphology
Mallory bodies
increased hepatocyte number
abnormal liver size
decreased susceptibility to diet-induced hepatic steatosis
hepatic steatosis
macrovesicular hepatic steatosis
microvesicular hepatic steatosis
liver fibrosis
pale liver
increased cholangiocarcinoma incidence
increased liver tumor incidence
increased hepatocellular carcinoma incidence
increased liver adenoma incidence
abnormal hepatocyte physiology
Availability Mouse Genotype
Ptentm1Rps/Pten+
Tg(Pten)1Srn/0
Ptentm1Hwu/Ptentm1Hwu
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Mx1-cre)1Cgn/0  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Alb1-cre)1Dlr/0  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Cdh5-cre)7Mlia/0  (conditional)
Ptentm2Mak/Ptentm2Mak
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+  (conditional)
Ptentm2Mak/Ptentm2Mak
Tg(Cyp1a1-cre)1Dwi/0  (conditional)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory