Symbol Name ID |
Hfe
homeostatic iron regulator MGI:109191 |
Darker colors indicate more annotations |
Human Phenotypes | Elevated hepatic iron concentration |
Hepatic steatosis |
Portal hypertension |
Hepatosplenomegaly |
Hepatomegaly |
Abnormality of the liver |
Hepatic lobular inflammation |
Cirrhosis |
Micronodular cirrhosis |
Hepatic fibrosis |
Periportal fibrosis |
Hepatocellular necrosis |
Hepatitis |
Chronic hepatitis |
Viral hepatitis |
Subacute progressive viral hepatitis |
Cholelithiasis |
Biliary cirrhosis |
Cholangiocarcinoma |
Cholestasis |
Prolonged neonatal jaundice |
Portal inflammation |
Hepatocellular carcinoma |
Disease(s) Associated with HFE | |||||||||||||||||||||||
beta thalassemia | |||||||||||||||||||||||
cystic fibrosis | |||||||||||||||||||||||
hemochromatosis | |||||||||||||||||||||||
hemochromatosis type 1 | |||||||||||||||||||||||
hepatocellular carcinoma | |||||||||||||||||||||||
metabolic dysfunction-associated steatotic liver disease | |||||||||||||||||||||||
myelofibrosis | |||||||||||||||||||||||
porphyria cutanea tarda |
Mouse Phenotypes | decreased liver iron level |
increased liver iron level |
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Availability | Mouse Genotype | ||
Hfetm1.1Jrco/Hfetm1.1Jrco | |||
Hfetm1.1Nca/Hfetm1.1Nca | |||
Hfetm1.1Wsr/Hfetm1.1Wsr | |||
Hfetm1Gfn/Hfetm1Gfn | |||
Hfetm1Sly/Hfetm1Sly | |||
Hfetm2Nca/Hfetm2Nca | |||
Hfetm2Nca/Hfetm2Nca Tg(Ttr-Hfe)1Nca/0 |
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Hfetm2Sly/Hfetm2Sly | |||
Hfetm3Sly/Hfetm3Sly | |||
Hfetm1Sly/Hfetm2Sly | |||
Hfetm2Nca/Hfe+ | |||
Hfetm2Sly/Hfetm3Sly | |||
Hfetm1Wsr/Hfetm1Wsr Tg(Alb1-cre)7Gsc/? (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/28/2024 MGI 6.13 |
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