Symbol
Name
ID

Gli3
GLI-Kruppel family member GLI3
MGI:95729

Phenotype annotations related to limbs/digits/tail

!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes

Clinodactyly of the 5th finger

Postaxial hand polydactyly

Shortening of all distal phalanges of the fingers

Complete duplication of distal phalanx of the thumb

Camptodactyly of finger

Broad thumb

Duplication of thumb phalanx

Mesoaxial hand polydactyly

Preaxial hand polydactyly

Symphalangism affecting the phalanges of the hand

Dysplastic distal thumb phalanges with a central hole

Triphalangeal thumb

Opposable triphalangeal thumb

Postaxial foot polydactyly

Broad hallux phalanx

Duplication of phalanx of hallux

Broad hallux

Preaxial foot polydactyly

Mesoaxial foot polydactyly

Sandal gap

Camptodactyly of toe

Toe syndactyly

1-3 toe syndactyly

1-5 toe syndactyly

2-3 toe syndactyly

Cutaneous syndactyly of toes

Oligodactyly

Mesoaxial polydactyly

Postaxial polydactyly

Preaxial polydactyly

Brachydactyly

Syndactyly

Cutaneous finger syndactyly

3-4 finger syndactyly

Y-shaped metatarsals

Short foot

Abnormal metacarpal morphology

Short 4th metacarpal

Y-shaped metacarpals

Short palm

Hip dislocation

Joint contracture of the hand

Distal shortening of limbs

Mesomelia

Disease(s) Associated with GLI3

Greig cephalopolysyndactyly syndrome

Pallister-Hall syndrome

polydactyly

syndactyly

Mouse Phenotypes

abnormal limb morphology

abnormal autopod morphology

decreased autopod size

abnormal digit morphology

abnormal hallux morphology

abnormal phalanx morphology

brachyphalangia

polyphalangy

adactyly

brachydactyly

oligodactyly

polydactyly

polysyndactyly

preaxial polydactyly

syndactyly

interdigital webbing

increased diameter of humerus

short humerus

abnormal forelimb zeugopod morphology

absent radius

bowed radius

short radius

increased diameter of radius

absent ulna

bowed ulna

short ulna

increased diameter of ulna

short forelimb

abnormal hindlimb morphology

short femur

short fibula

absent tibia

bowed tibia

short tibia

short hindlimb

camptomelia

abnormal digit development

abnormal embryonic autopod plate morphology

hemimelia

short limbs

Availability

Mouse Genotype

Gli3^add/Gli3^add

Gli3^Pdn/Gli3^Pdn

Gli3^TgBR/Gli3^TgBR

Gli3^tm1.2Zllr/Gli3^tm1.2Zllr

Gli3^tm1Blnw/Gli3^tm1Blnw

Gli3^tm1Urt/Gli3^tm1Urt

Gli3^tm2Blnw/Gli3^tm2Blnw

Gli3^Xt-2H/Gli3^Xt-2H

Gli3^Xt-3H/Gli3^Xt-3H

Gli3^Xt-5H/Gli3^Xt-5H

Gli3^Xt-6H/Gli3^Xt-6H

Gli3^Xt-7H/Gli3^Xt-7H

Gli3^Xt-J/Gli3^Xt-J

Gli3^Pdn/Gli3⁺

Gli3^TgBR/Gli3⁺

Gli3^tm1.2Zllr/Gli3^Xt-J

Gli3^tm1Blnw/Gli3^Xt-J

Gli3^tm1Urt/Gli3⁺

Gli3^tm1Urt/Gli3^tm2Blnw

Gli3^tm2Blnw/Gli3⁺

Gli3^Xt-2H/Gli3⁺

Gli3^Xt-3H/Gli3⁺

Gli3^Xt-4H/Gli3⁺

Gli3^Xt-5H/Gli3⁺

Gli3^Xt-6H/Gli3⁺

Gli3^Xt-J/Gli3⁺

Gli3^tm3.1Blnw/Gli3^tm3.1Blnw
Tg(Prrx1-cre)1Cjt/0 (conditional)

Gli3^tm1.1Zllr/Gli3^tm1.2Zllr
Hoxa13^{tm1.1(cre)Makm}/Hoxa13⁺ (conditional)

Gli3^tm3.1Blnw/Gli3⁺
Tg(Prrx1-cre)1Cjt/0 (conditional)

Gt(ROSA)26Sor^tm3(Gli3)Amc/Gt(ROSA)26Sor⁺
Tg(Prrx1-cre)1Cjt/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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