Symbol
Name
ID

Trp63
transformation related protein 63
MGI:1330810

Phenotype annotations related to limbs/digits/tail

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Clinodactyly of the 5th finger

Aplasia/Hypoplasia of the phalanges of the hand

Triphalangeal thumb

Aplasia/Hypoplasia of the phalanges of the toes

Toe syndactyly

2-3 toe syndactyly

2-3 toe cutaneous syndactyly

Syndactyly

Finger syndactyly

Aplasia/Hypoplasia of metatarsal bones

Aplasia/Hypoplasia involving the metacarpal bones

Ectrodactyly

Split foot

Split hand

Palmoplantar keratoderma

Disease(s) Associated with TP63

ADULT syndrome

ankyloblepharon-ectodermal defects-cleft lip/palate syndrome

ectrodactyly, ectodermal dysplasia, and cleft lip-palate syndrome 3

Rapp-Hodgkin syndrome

split hand-foot malformation 4

Mouse Phenotypes

limbs/digits/tail phenotype

abnormal apical ectodermal ridge morphology

absent apical ectodermal ridge

abnormal limb bud morphology

small limb buds

small tail bud

abnormal limb morphology

absent carpal bone

abnormal phalanx morphology

adactyly

ectrodactyly

abnormal forelimb morphology

abnormal humerus morphology

absent radius

absent ulna

short forelimb

absent hindlimb

abnormal limb bone morphology

abnormal limb development

absent limbs

short limbs

Availability

Mouse Genotype

Trp63^m1Mhda/Trp63^m1Mhda

Trp63^{tm1.1(cre)Ssig}/Trp63^{tm1.1(cre)Ssig}

Trp63^tm1Aam/Trp63^tm1Aam

Trp63^tm1Brd/Trp63^tm1Brd

Trp63^tm1Fmc/Trp63^tm1Fmc

Trp63^tm1Sin/Trp63^tm1Sin

Trp63^tm2Brd/Trp63^tm2Brd

Trp63^tm3.1Aam/Trp63^tm3.1Aam

Trp63^tm3.2Aam/Trp63^tm3.2Aam

Trp63^tm3.2Brd/Trp63^tm3.2Brd

Trp63^tm3Aam/Trp63^tm3Aam

Trp63^tm1Aam/Trp63⁺

Trp63^tm2.1Aam/Trp63^tm3.1Aam

Trp63^tm2.1Aam/Trp63^tm3.2Aam

Trp63^tm2.1Aam/Trp63^tm3Aam

Trp63^tm3Aam/Trp63⁺

Tg(KRT5-cre/PGR)1Der/0
Trp63^tm2Brd/Trp63^tm3.1Brd (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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