Symbol
Name
ID

Trp53
transformation related protein 53
MGI:98834

Phenotype annotations related to integument

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Breast carcinoma	Jaundice	Onycholysis	Hyperhidrosis	Axillary freckling	Multiple cafe-au-lait spots	Hypopigmentation of the skin	Pretibial myxedema	Basal cell carcinoma	Plexiform neurofibroma	Choroid plexus papilloma
Disease(s) Associated with TP53	Breast carcinoma	Jaundice	Onycholysis	Hyperhidrosis	Axillary freckling	Multiple cafe-au-lait spots	Hypopigmentation of the skin	Pretibial myxedema	Basal cell carcinoma	Plexiform neurofibroma	Choroid plexus papilloma
breast cancer
choroid plexus papilloma
Graves' disease
Li-Fraumeni syndrome
Li-Fraumeni syndrome 1
mismatch repair cancer syndrome
pancreatic cancer

Mouse Phenotypes

integument phenotype

decreased subcutaneous adipose tissue amount

increased ear pigmentation

abnormal mammary gland development

abnormal mammary gland growth during lactation

increased mammary gland tumor incidence

increased mammary adenocarcinoma incidence

abnormal mammary gland physiology

lactation failure

abnormal coat/ hair morphology

darkened coat color

alopecia

sparse hair

ruffled hair

nail dystrophy

abnormal hair follicle morphology

dilated hair follicle

hair follicle comedo

delayed hair regrowth

thin dermal layer

pallor

skin lesions

abnormal digit pigmentation

increased foot pad pigmentation

increased tail pigmentation

decreased sensitivity to skin irradiation

increased skin tumor incidence

increased pilomatricoma incidence

increased skin papilloma incidence

increased skin squamous cell carcinoma incidence

Availability

Mouse Genotype

Trp53^tm1.1Manf/Trp53^tm1.1Manf

Trp53^tm1.1Tldo/Trp53^tm1.1Tldo

Trp53^tm1.2Awbr/Trp53^tm1.2Awbr

Trp53^tm1Adv/Trp53^tm1Adv

Trp53^tm1Tyj/Trp53^tm1Tyj

Trp53^tm1Yjc/Trp53^tm1Yjc

Trp53^tm2Wahl/Trp53^tm2Wahl

Trp53^tm1.1Tldo/Trp53⁺

Trp53^tm1Adv/Trp53⁺

Trp53^tm1Ldo/Trp53⁺

Trp53^tm1Tyj/Trp53⁺

Trp53^tm3.1Tyj/Trp53⁺

Tg(Trp53A135V)L3Ber/0

Tg(Trp53R172H)8512Jmr/0

Tg(Trp53R172L)4491Jmr/0

Trp53^tm1.1Brn/Trp53^tm1.1Brn
Tg(KRT14-cre)8Brn/? (conditional)

Trp53^tm1Brn/Trp53^tm1Brn
Tg(KRT14-cre)8Brn/0 (conditional)

Trp53^tm1Brn/Trp53^tm1Brn
Tg(MMTV-cre)#Mam/0 (conditional)

Trp53^tm1Brn/Trp53^tm1Brn
Tg(MMTV-cre)105Ayn/0 (conditional)

Trp53^tm1Brn/Trp53^tm1Brn
Tg(KRT5-cre/PGR)1Der/0 (conditional)

Trp53^tm1Brn/Trp53^tm1Brn
Tg(MMTV-cre)#Tfln/0 (conditional)

Trp53^tm1Brn/Trp53^tm1Brn
Tg(Wap-cre)51Nki/0 (conditional)

Trp53^tm1Elee/Trp53^tm1Elee
Tg(MMTV-cre)AElee/0 (conditional)

Trp53^tm1Elee/Trp53^tm1Elee
Tg(MMTV-cre)BElee/0 (conditional)

Trp53^tm1Elee/Trp53^tm1Elee
Tg(Wap-rtTA-cre)10Whl/0 (conditional)

Trp53^tm1.1Brn/Trp53⁺
Tg(KRT14-cre)8Brn/? (conditional)

Trp53^tm1.1Brn/Trp53^tm3Tyj
Tg(KRT14-cre)8Brn/? (conditional)

Trp53^tm1Att/Trp53⁺
Tg(KRT5-cre)5132Jlj/0 (conditional)

Trp53^tm1Brn/Trp53⁺
Tg(MMTV-cre)#Tfln/0 (conditional)

Trp53^tm3Tyj/Trp53⁺
Tg(KRT14-cre)8Brn/? (conditional)

Trp53^tm3Tyj/Trp53⁺
Tg(Wap-cre)11738Mam/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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