Symbol
Name
ID

Trp63
transformation related protein 63
MGI:1330810

Phenotype annotations related to integument

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Alopecia of scalp

Sparse scalp hair

Sparse eyebrow

Absent eyelashes

Sparse eyelashes

Palmoplantar keratoderma

Wide intermamillary distance

Absent nipple

Hypoplastic nipples

Supernumerary nipple

Breast hypoplasia

Eczematoid dermatitis

Patchy alopecia

Progressive alopecia

Facial hirsutism

Sparse hair

Sparse axillary hair

Sparse body hair

Sparse pubic hair

Pili canaliculi

Pili torti

Slow-growing hair

Fair hair

Coarse hair

Fine hair

Uncombable hair

Decreased number of sweat glands

Dystrophic fingernails

Dystrophic toenail

Anonychia

Small nail

Hyperconvex nail

Hyperconvex fingernails

Nail pits

Nail dystrophy

Onychogryposis

Anhidrosis

Hypohidrosis

Freckling

Hyperpigmentation of the skin

Generalized hyperpigmentation

Generalized hypopigmentation

Dry skin

Cutaneous photosensitivity

Ectodermal dysplasia

Anhidrotic ectodermal dysplasia

Dermal atrophy

Thin skin

Adermatoglyphia

Hyperkeratosis

Disease(s) Associated with TP63

ADULT syndrome

ankyloblepharon-ectodermal defects-cleft lip/palate syndrome

ectrodactyly, ectodermal dysplasia, and cleft lip-palate syndrome 3

Rapp-Hodgkin syndrome

Mouse Phenotypes

integument phenotype

abnormal keratinocyte differentiation

decreased keratinocyte proliferation

absent mammary gland

absent sebaceous gland

impaired skin barrier function

alopecia

ruffled hair

abnormal hair shaft morphology

nail dystrophy

abnormal hair follicle development

absent hair follicles

decreased hair follicle number

absent vibrissae

abnormal skin morphology

thick dermal layer

abnormal epidermal layer morphology

abnormal epidermis stratum basale morphology

thick epidermis stratum basale

absent epidermis stratum corneum

absent epidermis stratum granulosum

abnormal epidermis stratum spinosum morphology

absent epidermis stratum spinosum

acanthosis

thick epidermis stratum spinosum

abnormal keratinocyte morphology

absent epidermis

thick epidermis

dermal-epidermal separation

blistering

shiny skin

skin lesions

spontaneous skin ulceration

translucent skin

wrinkled skin

abnormal skin condition

abnormal skin development

abnormal skin physiology

abnormal keratinocyte physiology

Availability

Mouse Genotype

Trp63^{tm1.1(cre)Ssig}/Trp63^{tm1.1(cre)Ssig}

Trp63^tm1.1Elrf/Trp63^tm1.1Elrf

Trp63^tm1Brd/Trp63^tm1Brd

Trp63^tm1Fmc/Trp63^tm1Fmc

Trp63^tm1Sin/Trp63^tm1Sin

Trp63^tm2.2Elrf/Trp63^tm2.2Elrf

Trp63^tm2Brd/Trp63^tm2Brd

Trp63^tm3.1Aam/Trp63^tm3.1Aam

Trp63^tm3.2Aam/Trp63^tm3.2Aam

Trp63^tm3.2Brd/Trp63^tm3.2Brd

Trp63^tm3Aam/Trp63^tm3Aam

Trp63^tm1Cmis/Trp63⁺

Trp63^tm2.1Aam/Trp63^tm3.1Aam

Trp63^tm2.1Aam/Trp63^tm3.2Aam

Trp63^tm2.1Aam/Trp63^tm3Aam

Trp63^tm2.2Elrf/Trp63⁺

Trp63^tm2Brd/Trp63⁺

Trp63^tm3.1Aam/Trp63⁺

Trp63^tm3Aam/Trp63⁺

Trp63^tm1Elrf/Trp63^tm1Elrf
Tg(KRT14-cre)8Brn/0 (conditional)

Tg(KRT5-cre/PGR)1Der/0
Trp63^tm2Brd/Trp63^tm3.1Brd (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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