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Symbol
Name
ID
Trp53
transformation related protein 53
MGI:98834
Phenotype annotations related to immune system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Increased circulating IgA level
Increased circulating IgG level
Decreased circulating antibody level
Paraproteinemia
Leukemia
Acute leukemia
Acute lymphoblastic leukemia
Acute myeloid leukemia
Lymphadenopathy
Splenomegaly
Hepatosplenomegaly
Peritoneal abscess
Subacute progressive viral hepatitis
Disease(s) Associated with TP53
acute myeloid leukemia
hepatocellular carcinoma
Li-Fraumeni syndrome
Li-Fraumeni syndrome 1
mismatch repair cancer syndrome
multiple myeloma
pancreatic cancer

Mouse Phenotypes
immune system phenotype
adipose tissue inflammation
abnormal thymocyte apoptosis
decreased thymocyte apoptosis
increased thymocyte apoptosis
decreased T cell apoptosis
decreased splenocyte apoptosis
decreased T cell proliferation
increased splenocyte proliferation
abnormal thymus morphology
increased thymus weight
small thymus
abnormal thymus physiology
hepatosplenomegaly
enlarged spleen
increased spleen weight
spleen hyperplasia
decreased neutrophil cell number
increased large unstained cell number
decreased leukocyte cell number
increased leukocyte cell number
abnormal lymphocyte morphology
abnormal spleen morphology
decreased spleen red pulp amount
decreased spleen weight
small spleen
spleen hypoplasia
abnormal spleen white pulp morphology
abnormal spleen marginal zone morphology
increased circulating interferon-gamma level
increased circulating interleukin-3 level
increased circulating interleukin-5 level
increased circulating interleukin-6 level
increased circulating tumor necrosis factor level
abnormal Peyer's patch morphology
abnormal abdominal lymph node morphology
increased inflammatory response
liver inflammation
lung inflammation
Availability Mouse Genotype
Gt(ROSA)26Sortm1.1(CAG-Trp53*,-EGFP)Medz/Gt(ROSA)26Sortm1.1(CAG-Trp53*,-EGFP)Medz
Trp53tm1.1Manf/Trp53tm1.1Manf
Trp53tm1.1Thst/Trp53tm1.1Thst *
Trp53tm1.1Tldo/Trp53tm1.1Tldo
Trp53tm1.1Wgu/Trp53tm1.1Wgu
Trp53tm1.2Awbr/Trp53tm1.2Awbr
Trp53tm1b(EUCOMM)Hmgu/Trp53tm1b(EUCOMM)Hmgu
Trp53tm1Brd/Trp53tm1Brd
Trp53tm1Glo/Trp53tm1Glo
Trp53tm1Sia/Trp53tm1Sia
Trp53tm1Thst/Trp53tm1Thst
Trp53tm1Tyj/Trp53tm1Tyj
Tg(Trp53)1Srn/0
Trp53tm1Tyj/Trp53tm1Tyj
Trp53tm1Xu/Trp53tm1Xu
Trp53tm1Yjc/Trp53tm1Yjc *
Trp53tm2.1Snj/Trp53tm2.1Snj
Trp53tm2.1Wgu/Trp53tm2.1Wgu
Trp53tm2Wahl/Trp53tm2Wahl
Trp53tm2Xu/Trp53tm2Xu
Trp53tm7.1Xu/Trp53tm7.1Xu
Trp53tm1.1Thst/Trp53+
Trp53tm1.2Awbr/Trp53+
Trp53tm1Brd/Trp53tm8Xu
Trp53tm1Holl/Trp53tm7.1Xu
Trp53tm1Ldo/Trp53+
Trp53tm1Thst/Trp53+
Trp53tm1Thst/Trp53tm1.1Thst
Trp53tm1Tyj/Trp53+
Trp53tm3.1Glo/Trp53+
Trp53tm7.1Xu/Trp53+
Tg(Trp53)1Srn/0
Tg(Trp53)bSrn/0
Tg(Trp53A135V)L3Ber/0
Tg(CMV-cre)1Cgn/0
Trp53tm4Att/Trp53+  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/21/2024
MGI 6.23
The Jackson Laboratory