Symbol Name ID |
Tcf3
transcription factor 3 MGI:98510 |
* | Aspects of the system are reported to show a normal phenotype. |
Darker colors indicate more annotations |
Human Phenotypes | Decreased circulating IgA level |
Decreased circulating IgE |
Decreased circulating IgG level |
Decreased circulating total IgM |
Agammaglobulinemia |
Partial absence of specific antibody response to tetanus vaccine |
B lymphocytopenia |
Decreased proportion of CD8-positive, alpha-beta TEMRA T cells |
Increased proportion of effector memory CD8-positive, alpha-beta T cells |
B Acute Lymphoblastic Leukemia |
Splenomegaly |
Recurrent otitis media |
Recurrent pneumonia |
Post-vaccination polio |
Recurrent infections |
Disease(s) Associated with TCF3 | |||||||||||||||
agammaglobulinemia 8A | |||||||||||||||
agammaglobulinemia 8B |
Mouse Phenotypes | immune system phenotype |
enlarged thymus |
thymus hypoplasia |
abnormal lymphopoiesis |
abnormal B cell differentiation |
decreased immature B cell number |
decreased transitional stage B cell number |
abnormal immunoglobulin V(D)J recombination |
abnormal immunoglobulin heavy chain V(D)J recombination |
abnormal immunoglobulin light chain V-J recombination |
decreased pro-B cell number |
absent pro-B cells |
arrested B cell differentiation |
increased double-negative T cell number |
decreased double-positive T cell number |
decreased dendritic cell number |
abnormal lymphocyte cell number |
abnormal B cell number |
decreased germinal center B cell number |
decreased mature B cell number |
increased marginal zone B cell number |
decreased B cell number |
absent B cells |
decreased pre-B cell number |
absent pre-B cells |
increased B cell number |
decreased NK cell number |
abnormal T cell subpopulation ratio |
increased single-positive T cell number |
decreased lymphocyte cell number |
abnormal germinal center B cell morphology |
spleen atrophy |
abnormal immune system morphology |
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Availability | Mouse Genotype | |||||||||||||||||||||||||||||||||
Tcf3tm1Cmu/Tcf3tm1Cmu | ||||||||||||||||||||||||||||||||||
Tcf3tm1Wein/Tcf3tm1Wein | ||||||||||||||||||||||||||||||||||
Tcf3tm1Xhsu/Tcf3tm1Xhsu | * | |||||||||||||||||||||||||||||||||
Tcf3tm1Zhu/Tcf3tm1Zhu | ||||||||||||||||||||||||||||||||||
Tcf3tm2Cmu/Tcf3tm2Cmu | ||||||||||||||||||||||||||||||||||
Tcf3tm2Wein/Tcf3tm2Wein | ||||||||||||||||||||||||||||||||||
Tcf3tm2Zhu/Tcf3tm2Zhu | ||||||||||||||||||||||||||||||||||
Tcf3tm3.1Cmu/Tcf3tm3.1Cmu | ||||||||||||||||||||||||||||||||||
Tcf3tm3Zhu/Tcf3tm3Zhu | * | |||||||||||||||||||||||||||||||||
Tcf3tm4.1Cmu/Tcf3tm4.1Cmu | ||||||||||||||||||||||||||||||||||
Tcf3tm5.1Cmu/Tcf3tm5.1Cmu | * | |||||||||||||||||||||||||||||||||
Tcf3tm6(Esr1*)Zhu/Tcf3tm6(Esr1*)Zhu | ||||||||||||||||||||||||||||||||||
Tcf3tm1.1Mbu/Tcf3+ | ||||||||||||||||||||||||||||||||||
Tcf3tm1Cmu/Tcf3+ | ||||||||||||||||||||||||||||||||||
Tcf3tm1Wein/Tcf3+ | ||||||||||||||||||||||||||||||||||
Tcf3tm1Wein/Tcf3tm3Zhu | ||||||||||||||||||||||||||||||||||
Tcf3tm1Zhu/Tcf3tm2Zhu | ||||||||||||||||||||||||||||||||||
Tcf3tm1Mbu/Tcf3tm1Mbu Commd10Tg(Vav1-icre)A2Kio/Commd10+ (conditional) |
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Tcf3tm1Mbu/Tcf3tm1Mbu Tg(Ikzf1-Tcfe2a,-GFP)1Mbu/0 Commd10Tg(Vav1-icre)A2Kio/Commd10+ (conditional) |
* | |||||||||||||||||||||||||||||||||
Tcf3tm4Zhu/Tcf3tm4Zhu Tg(Lck-cre)#Zhu/0 (conditional) |
* | |||||||||||||||||||||||||||||||||
Cd19tm1(cre)Cgn/Cd19+ Tcf3tm1Mbu/Tcf3tm1.2Mbu (conditional) |
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Tcf3tm1(TCF3/HLF)Homy/Tcf3+ Tg(Mx1-cre)1Cgn/0 (conditional) |
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Tcf3tm1Mbu/Tcf3tm1.2Mbu Tg(Fcer2a-cre)5Mbu/0 (conditional) |
* | |||||||||||||||||||||||||||||||||
Tcf3tm1Mbu/Tcf3tm1.2Mbu Tg(Aicda-cre)9Mbu/0 (conditional) |
* |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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