Symbol
Name
ID

Spp1
secreted phosphoprotein 1
MGI:98389

Phenotype annotations related to immune system

Darker colors indicate more annotations

Human Phenotypes	Increased circulating IgA level	Increased circulating IgG level	Decreased circulating antibody level	Paraproteinemia	Lymphadenopathy	Splenomegaly	Hepatosplenomegaly	Peritoneal abscess	Subacute progressive viral hepatitis	Anti-citrullinated protein antibody positivity	Rheumatoid factor positive
Disease(s) Associated with SPP1	Increased circulating IgA level	Increased circulating IgG level	Decreased circulating antibody level	Paraproteinemia	Lymphadenopathy	Splenomegaly	Hepatosplenomegaly	Peritoneal abscess	Subacute progressive viral hepatitis	Anti-citrullinated protein antibody positivity	Rheumatoid factor positive
biliary atresia
hepatocellular carcinoma
multiple myeloma
pancreatic cancer
rheumatoid arthritis

Mouse Phenotypes

abnormal macrophage chemotaxis

impaired macrophage chemotaxis

abnormal leukocyte migration

decreased dendritic cell number

increased lymphocyte cell number

decreased macrophage cell number

decreased osteoclast cell number

increased macrophage cell number

increased osteoclast cell number

decreased leukocyte cell number

abnormal macrophage morphology

abnormal microglial cell morphology

abnormal leukocyte physiology

abnormal macrophage physiology

abnormal osteoclast physiology

decreased circulating interleukin-6 level

abnormal chemokine level

abnormal immune system physiology

decreased susceptibility to type IV hypersensitivity reaction

decreased interferon-gamma secretion

increased interleukin-10 secretion

decreased interleukin-12 secretion

increased interleukin-4 secretion

decreased tumor necrosis factor secretion

decreased susceptibility to experimental autoimmune uveoretinitis

abnormal inflammatory response

decreased acute inflammation

granulomatous inflammation

abnormal response to infection

abnormal susceptibility to infection

decreased susceptibility to bacterial infection

decreased susceptibility to bacterial infection induced morbidity/mortality

increased susceptibility to bacterial infection

decreased susceptibility to Herpesvirales infection

Availability

Mouse Genotype

Spp1^tm1.1Dhd/Spp1^tm1.1Dhd

Spp1^tm1Blh/Spp1^tm1Blh

Spp1^tm1Rit/Spp1^tm1Rit

Spp1^Ric-r/Spp1⁺

Spp1^Ric-s/Spp1⁺

Spp1^tm1Blh/Spp1⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/14/2024 MGI 6.23