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Symbol
Name
ID 		Ccl2
C-C motif chemokine ligand 2
MGI:98259
Phenotype annotations related to immune system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Increased circulating IgA level
Increased circulating IgE level
Leukocytosis
Leukopenia
Severe periodontitis
Recurrent pharyngitis
Pericarditis
Lymphadenopathy
Mediastinal lymphadenopathy
Subacute progressive viral hepatitis
Pancreatitis
Iridocyclitis
Epididymitis
Lupus nephritis
Nephritis
Abnormality of the immune system
Eczematoid dermatitis
Erythema nodosum
Discoid lupus rash
Malar rash
Serositis
Decreased circulating complement C3 concentration
Decreased circulating complement C4 concentration
Antineutrophil antibody positivity
Perinuclear antineutrophil antibody positivity
Antinuclear antibody positivity
Anti-dsDNA antibody positivity
Anti-La/SS-B antibody positivity
Anti-Sm antibody positivity
Anti-U1 ribonucleoprotein antibody positivity
Antiphospholipid antibody positivity
Systemic lupus erythematosus
Asthma
Meningitis
Disease(s) Associated with CCL2
aggressive periodontitis
asthma
Behcet's disease
hepatocellular carcinoma
pancreatitis
systemic lupus erythematosus
temporal arteritis
thrombocytopenia

Mouse Phenotypes
immune system phenotype
abnormal dendritic cell chemotaxis
abnormal macrophage chemotaxis
impaired macrophage chemotaxis
abnormal leukocyte migration
decreased susceptibility to induced colitis
increased neutrophil cell number
decreased dendritic cell number
increased CD4-positive, alpha-beta T cell number
decreased lymphocyte cell number
decreased macrophage cell number
increased osteoclast cell number
decreased leukocyte cell number
abnormal monocyte morphology
abnormal neutrophil physiology
increased IgG1 level
increased IgG level
abnormal T cell physiology
abnormal macrophage physiology
abnormal microglial cell physiology
increased circulating interferon-gamma level
increased circulating interleukin-10 level
increased circulating tumor necrosis factor level
abnormal chemokine level
abnormal dendritic cell physiology
decreased susceptibility to type IV hypersensitivity reaction
abnormal cytokine secretion
abnormal chemokine secretion
decreased interferon-gamma secretion
decreased interleukin-1 beta secretion
increased interleukin-10 secretion
decreased interleukin-12b secretion
decreased interleukin-4 secretion
decreased interleukin-5 secretion
decreased susceptibility to experimental autoimmune encephalomyelitis
decreased inflammatory response
increased susceptibility to bacterial infection
increased susceptibility to infection induced morbidity/mortality
increased susceptibility to parasitic infection
Availability Mouse Genotype
Ccl2tm1.1Tyos/Ccl2tm1.1Tyos
Ccl2tm1Lex/Ccl2tm1Lex *
Ccl2tm1Rol/Ccl2tm1Rol
Ccl2tm1Rol/Ccl2tm1Rol
Tg(Ccr2-GFP)8Pam/0
Ccl2tm1Tyos/Ccl2tm1Tyos
Ccl12tm1.1Ifc/Ccl12tm1.1Ifc *
Ccl12tm1Ifc/Ccl12tm1Ifc *
Ccl2tm1.1Pame/Ccl2tm1.1Pame
Tg(Nes-cre)1Kln/0  (conditional)
Ccl2tm1.1Pame/Ccl2tm1.1Pame
Tg(Tek-cre)12Flv/0  (conditional)
Ccl2tm1.1Pame/Ccl2tm1.1Pame
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+  (conditional)		 *
Ccl2tm1.1Pame/Ccl2tm1.1Pame
Lyz2tm1(cre)Ifo/Lyz2+  (conditional)		 *
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/21/2024
MGI 6.23 		The Jackson Laboratory