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Symbol
Name
ID

Ptpn2
protein tyrosine phosphatase, non-receptor type 2
MGI:97806

Phenotype annotations related to immune system

!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Mouse Phenotypes

abnormal osteoclast differentiation

thymus atrophy

decreased thymocyte number

abnormal thymus involution

enlarged spleen

spleen hyperplasia

decreased immature B cell number

abnormal T cell differentiation

abnormal negative T cell selection

abnormal positive T cell selection

decreased double-positive T cell number

abnormal B cell number

decreased mature B cell number

decreased B-1 B cell number

decreased follicular B cell number

decreased marginal zone B cell number

increased mature B cell number

decreased B cell number

increased B cell number

increased pre-B cell number

abnormal T cell subpopulation ratio

decreased CD4-positive, alpha-beta T cell number

decreased T cell number

decreased single-positive T cell number

increased macrophage cell number

abnormal spleen morphology

increased spleen red pulp amount

increased splenocyte number

abnormal osteoclast physiology

abnormal lymph node morphology

enlarged lymph nodes

lymph node hyperplasia

increased interferon-gamma secretion

increased interleukin-12 secretion

increased tumor necrosis factor secretion

abnormal inflammatory response

increased inflammatory response

Availability

Mouse Genotype

Ptpn2^tm1Mtr/Ptpn2^tm1Mtr

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Ptpn2^tm2.1Ttig/Ptpn2^tm2.1Ttig

Ptpn2^tm1.1Kry/Ptpn2^tm1.1Kry
Tg(Col1a1-cre)1Kry/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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