|
Symbol Name ID |
Polb
polymerase (DNA directed), beta MGI:97740 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Lymphadenopathy |
Hepatosplenomegaly |
Peritoneal abscess |
| Disease(s) Associated with POLB | |||
| pancreatic cancer |
| Mouse Phenotypes | immune system phenotype |
increased splenocyte apoptosis |
salivary gland inflammation |
abnormal immunoglobulin heavy chain V(D)J recombination |
abnormal somatic hypermutation frequency |
increased germinal center B cell number |
increased T-helper 2 cell number |
abnormal spleen germinal center morphology |
increased spleen germinal center number |
increased IgG level |
enlarged cervical lymph nodes |
abnormal lymphatic vessel topology |
lymph node inflammation |
increased susceptibility to systemic lupus erythematosus |
increased anti-nuclear antigen antibody level |
glomerulonephritis |
dermatitis |
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| Availability | Mouse Genotype | |||||||||||||||||
| Polbtm1.1Jbsw/Polbtm1.1Jbsw | ||||||||||||||||||
| Polbtm1a(KOMP)Wtsi/Polbtm1a(KOMP)Wtsi | ||||||||||||||||||
| Polbtm1.1Jbsw/Polb+ | ||||||||||||||||||
| Polbtm1Rsky/Polbtm1Rsky Tg(Lck-cre)I57Jxm/0 (conditional) |
* | |||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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