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Symbol
Name
ID

Mdm2
transformed mouse 3T3 cell double minute 2
MGI:96952

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Leukocytosis	Abnormal granulocyte morphology	Abnormal basophil morphology	Ph-positive acute lymphoblastic leukemia	Chronic myelogenous leukemia	Myeloproliferative disorder	Splenomegaly	Subacute progressive viral hepatitis
Disease(s) Associated with MDM2	Leukocytosis	Abnormal granulocyte morphology	Abnormal basophil morphology	Ph-positive acute lymphoblastic leukemia	Chronic myelogenous leukemia	Myeloproliferative disorder	Splenomegaly	Subacute progressive viral hepatitis
chronic myeloid leukemia
hepatocellular carcinoma

Mouse Phenotypes

immune system phenotype

decreased thymocyte apoptosis

decreased thymus weight

thymus hypoplasia

decreased thymocyte number

enlarged spleen

abnormal B cell differentiation

decreased immature B cell number

decreased double-negative T cell number

decreased double-positive T cell number

decreased neutrophil cell number

decreased granulocyte number

decreased T cell number

decreased lymphocyte cell number

decreased leukocyte cell number

decreased spleen weight

spleen hypoplasia

Availability

Mouse Genotype

Mdm2^tm2.1Snj/Mdm2^tm2.1Snj

Mdm2^tm3.1Snj/Mdm2^tm3.1Snj

*

Mdm2^tm1Bay/Mdm2^tm1Mep

Mdm2^tm1Mep/Mdm2^tm1.1Mep

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/21/2024 MGI 6.23