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Symbol
Name
ID

Lyn
LYN proto-oncogene, Src family tyrosine kinase
MGI:96892

Phenotype annotations related to immune system

Darker colors indicate more annotations

Mouse Phenotypes

decreased B cell proliferation

increased B cell proliferation

peritoneal inflammation

small thymus

enlarged spleen

increased spleen weight

spleen hyperplasia

abnormal class switch recombination

decreased transitional stage B cell number

increased immature B cell number

abnormal myelopoiesis

myeloid hyperplasia

increased basophil cell number

increased eosinophil cell number

increased mast cell number

increased neutrophil cell number

increased granulocyte number

increased dendritic cell number

decreased mature B cell number

decreased B-1 B cell number

decreased follicular B cell number

decreased marginal zone B cell number

increased B-1 B cell number

increased plasma cell number

decreased B cell number

decreased T cell number

increased T cell number

increased activated T cell number

decreased lymphocyte cell number

increased macrophage cell number

increased monocyte cell number

decreased leukocyte cell number

increased leukocyte cell number

abnormal B cell morphology

abnormal spleen morphology

decreased spleen red pulp amount

decreased spleen weight

spleen hypoplasia

disorganized spleen B cell follicle

decreased spleen white pulp amount

increased spleen white pulp amount

abnormal leukocyte physiology

abnormal B cell physiology

abnormal B cell activation

increased IgA level

increased IgE level

increased IgG1 level

increased IgG2b level

decreased IgG level

increased IgG level

decreased IgM level

increased IgM level

increased immunoglobulin level

abnormal T cell activation

abnormal macrophage physiology

abnormal microglial cell physiology

abnormal circulating complement protein level

abnormal circulating cytokine level

abnormal circulating chemokine level

increased circulating interferon-gamma level

increased circulating interleukin-1 beta level

increased circulating interleukin-12 level

increased circulating interleukin-17 level

increased circulating interleukin-6 level

increased circulating tumor necrosis factor level

abnormal chemokine level

small Peyer's patches

enlarged lymph nodes

lymph node hyperplasia

abnormal dendritic cell physiology

abnormal level of surface class II molecules

impaired humoral immune response

increased susceptibility to systemic lupus erythematosus

increased autoantibody level

increased anti-nuclear antigen antibody level

increased anti-double stranded DNA antibody level

abnormal inflammatory response

increased inflammatory response

liver inflammation

glomerulonephritis

lung inflammation

skin inflammation

Availability

Mouse Genotype

Lyn^m1Anu/Lyn^m1Anu

Lyn^M1Btlr/Lyn^M1Btlr

Lyn^m2Anu/Lyn^m2Anu

Lyn^M2Btlr/Lyn^M2Btlr

Lyn^M3Btlr/Lyn^M3Btlr

Lyn^m4Btlr/Lyn^m4Btlr

Lyn^mld4/Lyn^mld4

Lyn^tm1Ard/Lyn^tm1Ard

Lyn^{tm1b(EUCOMM)Hmgu}/Lyn^{tm1b(EUCOMM)Hmgu}

Lyn^tm1Mhi/Lyn^tm1Mhi

Lyn^tm1Sor/Lyn^tm1Sor

Lyn^tm1Tya/Lyn^tm1Tya

Lyn^weeb/Lyn^weeb

Lyn^M1Btlr/Lyn⁺

Lyn^M2Btlr/Lyn⁺

Lyn^M3Btlr/Lyn⁺

Lyn^tm1.1Calo/Lyn^tm1.1Calo
Tg(Itgax-cre)1-1Reiz/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/28/2024 MGI 6.13