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Symbol
Name
ID

Krt1
keratin 1
MGI:96698

Phenotype annotations related to immune system

Darker colors indicate more annotations

Human Phenotypes	Erythroderma
Disease(s) Associated with KRT1	Erythroderma
epidermolytic hyperkeratosis 1

Mouse Phenotypes

abnormal thymus morphology

enlarged thymus

enlarged spleen

increased spleen weight

decreased NK cell number

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number

increased effector memory CD8-positive, alpha-beta T cell number

increased CD8-positive, naive alpha-beta T cell number

increased effector memory T-helper cell number

abnormal spleen morphology

abnormal circulating interleukin level

increased circulating interleukin-18 level

abnormal interleukin secretion

Availability

Mouse Genotype

Krt1^{em1(IMPC)Ccpcz}/Krt1^{em1(IMPC)Ccpcz}

Krt1^tm1Tmm/Krt1^tm1Tmm

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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