Symbol
Name
ID

Jak2
Janus kinase 2
MGI:96629

Phenotype annotations related to immune system

Darker colors indicate more annotations

Human Phenotypes	Leukocytosis	Hemophagocytosis	Acute leukemia	Acute myeloid leukemia	Chronic myelogenous leukemia	Myeloproliferative disorder	Splenomegaly
Disease(s) Associated with JAK2	Leukocytosis	Hemophagocytosis	Acute leukemia	Acute myeloid leukemia	Chronic myelogenous leukemia	Myeloproliferative disorder	Splenomegaly
acute myeloid leukemia
essential thrombocythemia
familial erythrocytosis 1
myelofibrosis
polycythemia vera

Mouse Phenotypes

enlarged spleen

increased spleen weight

abnormal myelopoiesis

myeloid hyperplasia

increased neutrophil cell number

increased granulocyte number

decreased B cell number

increased lymphocyte cell number

increased monocyte cell number

decreased leukocyte cell number

increased leukocyte cell number

abnormal spleen morphology

abnormal spleen red pulp morphology

increased spleen red pulp amount

abnormal spleen white pulp morphology

decreased spleen white pulp amount

spleen fibrosis

abnormal cytokine level

Availability

Mouse Genotype

Jak2^tm1.1Jlvl/Jak2^tm1.1Jlvl

Jak2^tm1.2Ble/Jak2⁺

Jak2^tm2.2Jlvl/Jak2⁺

Tg(H2-K^b-Jak2*V617F)2Shmd/0

Jak2^tm1Mohi/Jak2^tm1Mohi
Tg(Mx1-cre)1Cgn/0 (conditional)

Jak2^tm1.1Ble/Jak2⁺
Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ (conditional)

Jak2^{tm1(JAK2)Argr}/Jak2⁺
Dppa3^tm1(cre)Peli/Dppa3⁺ (conditional)

Jak2^{tm1(JAK2)Argr}/Jak2⁺
Tg(Mx1-cre)1Cgn/0 (conditional)

Jak2^tm1Mohi/Jak2⁺
Tg(Mx1-cre)1Cgn/0 (conditional)

Jak2^tm2.1Jlvl/Jak2⁺
Tg(Vav1-cre)#Cgp/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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